PDF(Pubmed)
Abstract：
The association of different types of tocopherols (vitamin E) with cognition might vary by the APOEɛ4 allele status.
We examined the association of dietary tocopherols with cognitive decline among participants with and without the APOEɛ4 allele over a median of 12 years.
2,193 participants from the Chicago Health and Aging Project were included in the analyses. Global cognition was assessed in three-year cycles. We used a 144-item FFQ to assess dietary intakes of tocopherols and hME Sequenom mass-array platform to assess APOE genotype. We used linear mixed effects models to examine the relationship between tocopherol from food sources and global cognitive decline.
The mean baseline age was 74.1 (SD = 5.9) years. Among APOEɛ4 carriers, participants in the highest quintile of intakes of dietary vitamin E had a slower cognitive decline of 0.022 SDU (95% CI: 0.000, 0.043) compared to those in the lowest quintile. A higher intake of dietary α-tocopherol from food sources only was associated with slower cognitive decline in APOEɛ4 carriers (p for trend 0.002) but not among the non-carriers (p for trend 0.937). Among APOEɛ4 carriers, those in the highest quintile of intake of α-tocopherol had a 16.4% slower rate of decline of global cognition compared to those in the lowest quintile (β= 0.034, 95% CI: 0.013, 0.054).
Individuals consuming high α-tocopherol from food sources had slower cognitive decline among APOEɛ4 carriers. In older adults, different forms of vitamin E might moderate the relationship of APOEɛ4 with global cognition.
We examined the association of dietary tocopherols with cognitive decline among participants with and without the APOEɛ4 allele over a median of 12 years.
2,193 participants from the Chicago Health and Aging Project were included in the analyses. Global cognition was assessed in three-year cycles. We used a 144-item FFQ to assess dietary intakes of tocopherols and hME Sequenom mass-array platform to assess APOE genotype. We used linear mixed effects models to examine the relationship between tocopherol from food sources and global cognitive decline.
The mean baseline age was 74.1 (SD = 5.9) years. Among APOEɛ4 carriers, participants in the highest quintile of intakes of dietary vitamin E had a slower cognitive decline of 0.022 SDU (95% CI: 0.000, 0.043) compared to those in the lowest quintile. A higher intake of dietary α-tocopherol from food sources only was associated with slower cognitive decline in APOEɛ4 carriers (p for trend 0.002) but not among the non-carriers (p for trend 0.937). Among APOEɛ4 carriers, those in the highest quintile of intake of α-tocopherol had a 16.4% slower rate of decline of global cognition compared to those in the lowest quintile (β= 0.034, 95% CI: 0.013, 0.054).
Individuals consuming high α-tocopherol from food sources had slower cognitive decline among APOEɛ4 carriers. In older adults, different forms of vitamin E might moderate the relationship of APOEɛ4 with global cognition.
摘要：
背景：不同类型的生育酚（维生素E）与认知的关联可能因APOE4等位基因状态而异。
目的：我们研究了有和没有APOE4等位基因的参与者在12年的中位数中饮食生育酚与认知功能下降的关系。
方法：来自芝加哥健康与衰老项目的2,193名参与者被纳入分析。全球认知以三年为周期进行评估。我们使用144项FFQ来评估生育酚的饮食摄入量和hMESequenom质量阵列平台来评估APOE基因型。我们使用线性混合效应模型来研究食物来源的生育酚与全球认知能力下降之间的关系。
结果：平均基线年龄为74.1(SD=5.9)岁。在APOE4携带者中，膳食维生素E摄入量最高的1/5的参与者认知下降速度比最低的1/5的参与者慢,为0.022SDU(95%CI:0.000,0.043).从食物来源摄入较高的膳食α-生育酚仅与APOE4携带者的认知下降有关（趋势0.002的p），而非携带者则没有（趋势0.937的p）。在APOE4携带者中，与最低的五分之一人群相比,摄入α-生育酚最高的五分之一人群的全球认知下降率慢16.4%(β=0.034,95%CI:0.013,0.054).
结论：从食物来源摄入高α-生育酚的个体在APOE4携带者中认知能力下降较慢。在老年人中,不同形式的维生素E可能会缓解APOE4与全球认知的关系。
目的：我们研究了有和没有APOE4等位基因的参与者在12年的中位数中饮食生育酚与认知功能下降的关系。
方法：来自芝加哥健康与衰老项目的2,193名参与者被纳入分析。全球认知以三年为周期进行评估。我们使用144项FFQ来评估生育酚的饮食摄入量和hMESequenom质量阵列平台来评估APOE基因型。我们使用线性混合效应模型来研究食物来源的生育酚与全球认知能力下降之间的关系。
结果：平均基线年龄为74.1(SD=5.9)岁。在APOE4携带者中，膳食维生素E摄入量最高的1/5的参与者认知下降速度比最低的1/5的参与者慢,为0.022SDU(95%CI:0.000,0.043).从食物来源摄入较高的膳食α-生育酚仅与APOE4携带者的认知下降有关（趋势0.002的p），而非携带者则没有（趋势0.937的p）。在APOE4携带者中，与最低的五分之一人群相比,摄入α-生育酚最高的五分之一人群的全球认知下降率慢16.4%(β=0.034,95%CI:0.013,0.054).
结论：从食物来源摄入高α-生育酚的个体在APOE4携带者中认知能力下降较慢。在老年人中,不同形式的维生素E可能会缓解APOE4与全球认知的关系。
