PDF(Pubmed)
Abstract：
Circulating cytokines play a crucial role in the onset and progression of immune skin diseases. However, the causal relationships and the direction of causal effects require further investigation.
Two-sample Mendelian randomization (MR) analyses were conducted to assess the causal relationships between 41 circulating cytokines and six immune skin diseases including alopecia areata, chloasma, hidradenitis suppurativa (HS), lichen planus (LP), seborrheic dermatitis, and urticaria, using summary statistics from genome-wide association studies. Reverse MR analyses was performed to test for the reverse causation. Pleiotropy and heterogeneity tests were conducted to assess the robustness of the findings.
Twelve unique cytokines showed a suggestive causal relationship with the risk of six immune skin diseases. Among them, the causal effects between 9 unique cytokines and immune skin diseases have strong statistical power. Additionally, the concentrations of six cytokines might be influenced by LP and urticaria. After Bonferroni correction, the following associations remained significant: the causal effect of beta-nerve growth factor on HS (odds ratio [OR] = 1.634, 95% confidence interval [CI] = 1.226-2.177, p = 7.97e-04), interleukin (IL)-6 on LP (OR = 0.615, 95% CI = 0.481-0.786, p = 1.04e-04), IL-4 on LP (OR = 1.099. 95% CI = 1.020-1.184, p = 1.26e-02), and IL-2 on urticaria (OR = 0.712, 95% CI = 0.531-0.955, p = 2.33e-02).
This study provides novel perspectives on the relationship between circulating cytokines and immune skin diseases, potentially providing valuable insights into their etiology, diagnostic approaches, and treatment.
Two-sample Mendelian randomization (MR) analyses were conducted to assess the causal relationships between 41 circulating cytokines and six immune skin diseases including alopecia areata, chloasma, hidradenitis suppurativa (HS), lichen planus (LP), seborrheic dermatitis, and urticaria, using summary statistics from genome-wide association studies. Reverse MR analyses was performed to test for the reverse causation. Pleiotropy and heterogeneity tests were conducted to assess the robustness of the findings.
Twelve unique cytokines showed a suggestive causal relationship with the risk of six immune skin diseases. Among them, the causal effects between 9 unique cytokines and immune skin diseases have strong statistical power. Additionally, the concentrations of six cytokines might be influenced by LP and urticaria. After Bonferroni correction, the following associations remained significant: the causal effect of beta-nerve growth factor on HS (odds ratio [OR] = 1.634, 95% confidence interval [CI] = 1.226-2.177, p = 7.97e-04), interleukin (IL)-6 on LP (OR = 0.615, 95% CI = 0.481-0.786, p = 1.04e-04), IL-4 on LP (OR = 1.099. 95% CI = 1.020-1.184, p = 1.26e-02), and IL-2 on urticaria (OR = 0.712, 95% CI = 0.531-0.955, p = 2.33e-02).
This study provides novel perspectives on the relationship between circulating cytokines and immune skin diseases, potentially providing valuable insights into their etiology, diagnostic approaches, and treatment.
摘要：
循环细胞因子在免疫性皮肤病的发生和发展中起着至关重要的作用。然而,因果关系和因果效应的方向需要进一步调查。
进行了双样本孟德尔随机化（MR）分析，以评估41种循环细胞因子与包括斑秃在内的6种免疫性皮肤病之间的因果关系。黄褐斑,化脓性汗腺炎（HS），扁平苔藓(LP),脂溢性皮炎,和荨麻疹,使用全基因组关联研究的汇总统计数据。进行反向MR分析以测试反向因果关系。进行了多效性和异质性测试以评估研究结果的稳健性。
12种独特的细胞因子显示出与6种免疫性皮肤病风险之间的因果关系。其中,9种独特的细胞因子与免疫性皮肤病之间的因果效应具有很强的统计力。此外,6种细胞因子的浓度可能受LP和荨麻疹的影响。Bonferroni校正后,以下关联仍然是显著的:β-神经生长因子对HS的因果效应(比值比[OR]=1.634,95%置信区间[CI]=1.226-2.177,p=7.97e-04),白细胞介素（IL）-6对LP（OR=0.615，95％CI=0.481-0.786，p=1.04e-04），IL-4对LP(OR=1.099。95%CI=1.020-1.184，p=1.26e-02)，IL-2对荨麻疹的影响(OR=0.712,95%CI=0.531-0.955,p=2.33e-02)。
这项研究为循环细胞因子与免疫性皮肤病之间的关系提供了新的视角。可能为他们的病因提供有价值的见解，诊断方法，和治疗。
进行了双样本孟德尔随机化（MR）分析，以评估41种循环细胞因子与包括斑秃在内的6种免疫性皮肤病之间的因果关系。黄褐斑,化脓性汗腺炎（HS），扁平苔藓(LP),脂溢性皮炎,和荨麻疹,使用全基因组关联研究的汇总统计数据。进行反向MR分析以测试反向因果关系。进行了多效性和异质性测试以评估研究结果的稳健性。
12种独特的细胞因子显示出与6种免疫性皮肤病风险之间的因果关系。其中,9种独特的细胞因子与免疫性皮肤病之间的因果效应具有很强的统计力。此外,6种细胞因子的浓度可能受LP和荨麻疹的影响。Bonferroni校正后,以下关联仍然是显著的:β-神经生长因子对HS的因果效应(比值比[OR]=1.634,95%置信区间[CI]=1.226-2.177,p=7.97e-04),白细胞介素（IL）-6对LP（OR=0.615，95％CI=0.481-0.786，p=1.04e-04），IL-4对LP(OR=1.099。95%CI=1.020-1.184，p=1.26e-02)，IL-2对荨麻疹的影响(OR=0.712,95%CI=0.531-0.955,p=2.33e-02)。
这项研究为循环细胞因子与免疫性皮肤病之间的关系提供了新的视角。可能为他们的病因提供有价值的见解，诊断方法，和治疗。
