Abstract：
OBJECTIVE: A correlation between neutrophil extracellular traps (NETs) and ischemic stroke (IS) has been hypothesized, but the results of relevant studies remain controversial. The purpose was to determine whether NETs have an impact on ischemic stroke.
METHODS: The studies on the correlation between NETs and IS were retrieved from CNKI, Wanfang Data, VIP, CBM, PubMed, Web of Science, Embase, and Cochrane databases by computer from the start of the database to December 2022. The study adhered to PRISMA guidelines. The PICOS model was used to create inclusion criteria. Two researchers screened the literature and extracted the relevant data. The quality of the included studies was evaluated using the NOS and the 11 items recommended by the AHRQ, and meta-analysis was completed using Stata 15.1 software.
RESULTS: The researchers included 752 patients in 7 studies (4 case-control studies and 3 cross-sectional studies). The meta-analysis found NETs are positively associated with the severity of IS at the time of onset [r(95% CI) = 0.31(0.24, 0.38), P < 0.001]. NETs are positively associated with a worse prognosis of IS [r(95% CI) = 0.34(0.13, 0.53), P = 0.003].
CONCLUSIONS: The presence of NETs is positively related to the severity and prognosis of IS. Higher levels of NETs indicate a more severe disease and a poorer prognosis. Because the number and quality of included studies are limited, the above results must be supported by further high-quality studies.
BACKGROUND: https://www.crd.york.ac.uk/PROSPERO/ , identifier: CRD42022356619.
METHODS: The studies on the correlation between NETs and IS were retrieved from CNKI, Wanfang Data, VIP, CBM, PubMed, Web of Science, Embase, and Cochrane databases by computer from the start of the database to December 2022. The study adhered to PRISMA guidelines. The PICOS model was used to create inclusion criteria. Two researchers screened the literature and extracted the relevant data. The quality of the included studies was evaluated using the NOS and the 11 items recommended by the AHRQ, and meta-analysis was completed using Stata 15.1 software.
RESULTS: The researchers included 752 patients in 7 studies (4 case-control studies and 3 cross-sectional studies). The meta-analysis found NETs are positively associated with the severity of IS at the time of onset [r(95% CI) = 0.31(0.24, 0.38), P < 0.001]. NETs are positively associated with a worse prognosis of IS [r(95% CI) = 0.34(0.13, 0.53), P = 0.003].
CONCLUSIONS: The presence of NETs is positively related to the severity and prognosis of IS. Higher levels of NETs indicate a more severe disease and a poorer prognosis. Because the number and quality of included studies are limited, the above results must be supported by further high-quality studies.
BACKGROUND: https://www.crd.york.ac.uk/PROSPERO/ , identifier: CRD42022356619.
摘要：
目的：假设中性粒细胞胞外陷阱（NETs）与缺血性卒中（IS）之间存在相关性，但是相关研究的结果仍然存在争议。目的是确定NETs是否对缺血性卒中有影响。
方法：从CNKI检索有关NETs与IS相关性的研究,万方数据,VIP,CBM,PubMed,WebofScience,Embase,和Cochrane数据库从数据库开始到2022年12月。该研究遵循PRISMA指南。PICOS模型用于创建纳入标准。两位研究者筛选了文献并提取了相关数据。采用NOS和AHRQ推荐的11项评价纳入研究的质量,使用Stata15.1软件完成荟萃分析。
结果：研究人员在7项研究（4项病例对照研究和3项横断面研究）中纳入了752例患者。荟萃分析发现，NETs与发病时IS的严重程度呈正相关[r（95％CI）=0.31（0.24，0.38），P<0.001]。NET与IS预后较差呈正相关[r（95%CI）=0.34（0.13，0.53），P=0.003]。
结论：NETs的存在与IS的严重程度和预后呈正相关。较高水平的NETs表明疾病更严重和预后较差。由于纳入研究的数量和质量有限，上述结果必须得到进一步高质量研究的支持。
背景：https://www.crd.约克。AC.英国/PROSPERO/,标识符：CRD42022356619。
方法：从CNKI检索有关NETs与IS相关性的研究,万方数据,VIP,CBM,PubMed,WebofScience,Embase,和Cochrane数据库从数据库开始到2022年12月。该研究遵循PRISMA指南。PICOS模型用于创建纳入标准。两位研究者筛选了文献并提取了相关数据。采用NOS和AHRQ推荐的11项评价纳入研究的质量,使用Stata15.1软件完成荟萃分析。
结果：研究人员在7项研究（4项病例对照研究和3项横断面研究）中纳入了752例患者。荟萃分析发现，NETs与发病时IS的严重程度呈正相关[r（95％CI）=0.31（0.24，0.38），P<0.001]。NET与IS预后较差呈正相关[r（95%CI）=0.34（0.13，0.53），P=0.003]。
结论：NETs的存在与IS的严重程度和预后呈正相关。较高水平的NETs表明疾病更严重和预后较差。由于纳入研究的数量和质量有限，上述结果必须得到进一步高质量研究的支持。
背景：https://www.crd.约克。AC.英国/PROSPERO/,标识符：CRD42022356619。
