Abstract：
BACKGROUND: The impact of the new 2021 European Respiratory Society (ERS)/American Thoracic Society (ATS) pulmonary function test interpretation guidelines on the interpretation of bronchodilator responsiveness (BDR) in subjects with airway obstruction is still required. Therefore, the objective of this study was to explore the agreement between the 2005 and 2021 ERS/ATS criteria regarding the interpretation of the BDR. Moreover, we explore the factors that influenced the discordance of positive bronchodilator responsiveness (BDR+) between these two criteria.
METHODS: The agreement regarding the interpretation of BDR + between the two criteria was assessed using kappa (κ). The percentage of agreement in the interpretation of BDR + between the two criteria was calculated. The factors that influenced the discordance of BDR + between these two criteria were also analyzed.
RESULTS: A total of 500 subjects with a mean age of 60.5 ± 15.6 years, 62.2% male were included. The study observed a good level of agreement in the interpretation of BDR + between the two criteria with kappa values = 0.782. The percentages of agreement on the interpretation of BDR + between the two criteria were high, with values = 90.6%. Male sex was the only factor that influenced the discordance of BDR + between these two criteria.
CONCLUSIONS: A good level of agreement was observed in the interpretation of BDR + between the 2005 and 2021 criteria. Therefore, the 2005 and 2021 ERS/ATS criteria for BDR can be used interchangeably. However, the discordance of BDR + between these two criteria could be affected by sex.
METHODS: The agreement regarding the interpretation of BDR + between the two criteria was assessed using kappa (κ). The percentage of agreement in the interpretation of BDR + between the two criteria was calculated. The factors that influenced the discordance of BDR + between these two criteria were also analyzed.
RESULTS: A total of 500 subjects with a mean age of 60.5 ± 15.6 years, 62.2% male were included. The study observed a good level of agreement in the interpretation of BDR + between the two criteria with kappa values = 0.782. The percentages of agreement on the interpretation of BDR + between the two criteria were high, with values = 90.6%. Male sex was the only factor that influenced the discordance of BDR + between these two criteria.
CONCLUSIONS: A good level of agreement was observed in the interpretation of BDR + between the 2005 and 2021 criteria. Therefore, the 2005 and 2021 ERS/ATS criteria for BDR can be used interchangeably. However, the discordance of BDR + between these two criteria could be affected by sex.
摘要：
背景：仍然需要新的2021年欧洲呼吸学会（ERS）/美国胸科学会（ATS）肺功能测试解释指南对气道阻塞受试者的支气管扩张剂反应性（BDR）的解释的影响。因此,这项研究的目的是探讨2005年和2021年ERS/ATS标准之间关于BDR解释的协议.此外，我们探讨了影响这两个标准之间支气管扩张剂阳性反应性(BDR+)不一致的因素.
方法：使用κ(κ)评估两个标准之间关于BDR+解释的一致性。计算了两个标准之间对BDR+的解释的一致性百分比。还分析了影响这两个标准之间BDR不一致的因素。
结果：共有500名受试者，平均年龄为60.5±15.6岁，62.2%为男性。该研究观察到在Kappa值=0.782的两个标准之间对BDR+的解释具有良好的一致性。这两个标准对BDR+解释的一致性百分比很高，值=90.6%。男性是影响这两个标准之间BDR不一致的唯一因素。
结论：在2005年和2021年标准之间对BDR+的解释中观察到了良好的一致性。因此,2005年和2021年BDR的ERS/ATS标准可以互换使用。然而,这两个标准之间BDR+的不一致可能受到性别的影响.
方法：使用κ(κ)评估两个标准之间关于BDR+解释的一致性。计算了两个标准之间对BDR+的解释的一致性百分比。还分析了影响这两个标准之间BDR不一致的因素。
结果：共有500名受试者，平均年龄为60.5±15.6岁，62.2%为男性。该研究观察到在Kappa值=0.782的两个标准之间对BDR+的解释具有良好的一致性。这两个标准对BDR+解释的一致性百分比很高，值=90.6%。男性是影响这两个标准之间BDR不一致的唯一因素。
结论：在2005年和2021年标准之间对BDR+的解释中观察到了良好的一致性。因此,2005年和2021年BDR的ERS/ATS标准可以互换使用。然而,这两个标准之间BDR+的不一致可能受到性别的影响.
