Abstract：
Great progress continues to be made in our understanding of the multiple facets of osteoarthritis (OA) biology. Here, we review the major advances in this field and progress towards therapy development over the past year, highlighting a selection of relevant published literature from a PubMed search covering the year from the end of April 2022 to the end of April 2023. The selected articles have been arranged in themes. These include 1) molecular regulation of articular cartilage and implications for OA, 2) mechanisms of subchondral bone remodelling, 3) role of synovium and inflammation, 4) role of age-related changes including cartilage matrix stiffening, cellular senescence, mitochondrial dysfunction, metabolic dysfunction, and impaired autophagy, and 5) peripheral mechanisms of OA pain. Progress in the understanding of the cellular and molecular mechanisms responsible for the multiple aspects of OA biology is unravelling novel therapeutic targets for disease modification.
摘要：
在我们对骨关节炎（OA）生物学的多个方面的理解方面继续取得重大进展。这里,我们回顾了过去一年该领域的主要进展和治疗进展，突出显示从PubMed搜索中选择的相关已发表文献，涵盖2022年4月底至2023年4月底的一年。选定的文章已按主题排列。这些包括1）关节软骨的分子调节和对OA的影响，2)软骨下骨重塑的机制，3）滑膜和炎症的作用，4）年龄相关变化的作用，包括软骨基质硬化，细胞衰老,线粒体功能障碍，代谢功能障碍，和自噬受损，和5)OA疼痛的外周机制。对负责OA生物学多个方面的细胞和分子机制的理解的进展正在揭示疾病修饰的新治疗靶标。
