PDF(Pubmed)
Abstract：
UNASSIGNED: Lambert-Eaton myasthenia syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies targeting presynaptic neuromuscular junctions. It results in muscle weakness and autonomic dysfunction. LEMS can be idiopathic or associated with neoplastic diseases, often small-cell lung cancer. This case report describes a rare instance of paraneoplastic LEMS in a man with non-Hodgkin lymphoma.
UNASSIGNED: A 57-year-old male with non-Hodgkin lymphoma presented with progressive muscle weakness, diminished reflexes, and autonomic symptoms. Diagnosis revealed LEMS with autoantibodies against voltage-gated calcium channels. Immunosuppressive therapy and lymphoma treatment led to significant improvement in his condition.
UNASSIGNED: This case highlights the rare occurrence of paraneoplastic LEMS in a patient with non-Hodgkin lymphoma. Recognition and timely management of LEMS alongside lymphoma treatment can lead to significant clinical improvement, emphasizing the need for increased awareness of such complex associations.
UNASSIGNED: A 57-year-old male with non-Hodgkin lymphoma presented with progressive muscle weakness, diminished reflexes, and autonomic symptoms. Diagnosis revealed LEMS with autoantibodies against voltage-gated calcium channels. Immunosuppressive therapy and lymphoma treatment led to significant improvement in his condition.
UNASSIGNED: This case highlights the rare occurrence of paraneoplastic LEMS in a patient with non-Hodgkin lymphoma. Recognition and timely management of LEMS alongside lymphoma treatment can lead to significant clinical improvement, emphasizing the need for increased awareness of such complex associations.
摘要：
■Lambert-Eaton肌无力综合征（LEMS）是一种罕见的自身免疫性疾病，其特征是针对突触前神经肌肉接头的自身抗体。它导致肌肉无力和自主神经功能障碍。LEMS可以是特发性的或与肿瘤疾病相关的，通常是小细胞肺癌。此病例报告描述了一名患有非霍奇金淋巴瘤的男性中罕见的副肿瘤LEMS。
■一名57岁的非霍奇金淋巴瘤男性，表现为进行性肌无力，反射减弱,和自主神经症状。诊断显示LEMS具有针对电压门控钙通道的自身抗体。免疫抑制治疗和淋巴瘤治疗导致他的病情显着改善。
■该病例突出了非霍奇金淋巴瘤患者中罕见的副肿瘤LEMS的发生。识别和及时管理LEMS以及淋巴瘤治疗可以导致显著的临床改善，强调需要提高对这种复杂关联的认识。
■一名57岁的非霍奇金淋巴瘤男性，表现为进行性肌无力，反射减弱,和自主神经症状。诊断显示LEMS具有针对电压门控钙通道的自身抗体。免疫抑制治疗和淋巴瘤治疗导致他的病情显着改善。
■该病例突出了非霍奇金淋巴瘤患者中罕见的副肿瘤LEMS的发生。识别和及时管理LEMS以及淋巴瘤治疗可以导致显著的临床改善，强调需要提高对这种复杂关联的认识。
