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Abstract：
OBJECTIVE: To report 5-year outcomes after surgery for cataract associated with persistent fetal vasculature (PFV).
METHODS: Clinical cohort study using pediatric cataract registry data collected annually from medical records.
METHODS: This study included 64 children <13 years of age who were undergoing surgery for unilateral, nontraumatic cataract associated with PFV. Proportions with age-normal visual acuity (VA) and VA better than 20/200 at 5 years\' follow-up were estimated. Cumulative incidences of complications and additional surgeries by 5 years were calculated. Outcomes were compared between eyes with unilateral PFV and eyes with unilateral non-PFV cataract from our registry.
RESULTS: Forty-eight of 64 eyes were aphakic postoperatively (median age at surgery 2 months [range 1-13 months]) and 16 were pseudophakic (29 months [range 2-92 months]). Overall, 4 of 42 eyes (10% [95% confidence interval {CI} 3%-23%]) achieved age-normal VA. VA better than 20/200 was achieved in 17 (59% [95% CI 39%-76%]) unilateral aphakic PFV eyes and 44 (43% [95% CI 32%-54%]) unilateral non-PFV aphakic eyes (age-adjusted odds ratio = 1.90 [95% CI 0.81-4.50]; P = .14). The most common complication in aphakic PFV eyes was glaucoma-related adverse events (cumulative incidence 24% [95% CI 9%-37%]). There was no significant difference in glaucoma-related adverse events between PFV and non-PFV eyes in aphakic participants ≤1 year of age at lensectomy (age-adjusted hazard ratio = 1.20 [95% CI 0.54-2.64], P = .66).
CONCLUSIONS: A wide range of visual outcomes for PFV cataract were observed with a 10% probability of achieving age-normal VA. There was an ongoing risk for the development of glaucoma-related adverse events in PFV eyes.
METHODS: Clinical cohort study using pediatric cataract registry data collected annually from medical records.
METHODS: This study included 64 children <13 years of age who were undergoing surgery for unilateral, nontraumatic cataract associated with PFV. Proportions with age-normal visual acuity (VA) and VA better than 20/200 at 5 years\' follow-up were estimated. Cumulative incidences of complications and additional surgeries by 5 years were calculated. Outcomes were compared between eyes with unilateral PFV and eyes with unilateral non-PFV cataract from our registry.
RESULTS: Forty-eight of 64 eyes were aphakic postoperatively (median age at surgery 2 months [range 1-13 months]) and 16 were pseudophakic (29 months [range 2-92 months]). Overall, 4 of 42 eyes (10% [95% confidence interval {CI} 3%-23%]) achieved age-normal VA. VA better than 20/200 was achieved in 17 (59% [95% CI 39%-76%]) unilateral aphakic PFV eyes and 44 (43% [95% CI 32%-54%]) unilateral non-PFV aphakic eyes (age-adjusted odds ratio = 1.90 [95% CI 0.81-4.50]; P = .14). The most common complication in aphakic PFV eyes was glaucoma-related adverse events (cumulative incidence 24% [95% CI 9%-37%]). There was no significant difference in glaucoma-related adverse events between PFV and non-PFV eyes in aphakic participants ≤1 year of age at lensectomy (age-adjusted hazard ratio = 1.20 [95% CI 0.54-2.64], P = .66).
CONCLUSIONS: A wide range of visual outcomes for PFV cataract were observed with a 10% probability of achieving age-normal VA. There was an ongoing risk for the development of glaucoma-related adverse events in PFV eyes.
摘要：
目的：报告持续性胎儿血管（PFV）相关白内障手术后5年的结局。
方法：使用每年从医疗记录中收集的儿童白内障登记数据进行临床队列研究。
方法：64名13岁以下儿童，接受单侧手术，包括与PFV相关的非创伤性白内障。估计了5年随访时年龄正常视力（VA）和VA优于20/200的比例。计算5年的并发症和额外手术的累积发生率。从我们的注册表中比较了单侧PFV和单侧非PFV白内障的结果。
结果：64只眼中的48只眼术后无晶状体（手术时的中位年龄为2个月，范围1-13)和16是假晶状体(29个月，范围2到92)。总的来说,42只眼睛中的4只（10％，95%CI：3%-23%）达到年龄正常视力。VA优于20/200在17个(59%，95%CI39%-76%)单侧无晶状体PFV眼和44(43%，95%CI32%-54%)单侧非PFV无晶状体眼(年龄校正OR=1.90;95%CI:0.81-4.50;P=0.14)。无晶状体PFV眼最常见的并发症是青光眼相关不良事件（GRAE）（累积发生率24%，95%CI：9%-37%）。在晶状体切除术中年龄≤1岁的无晶状体参与者中，PFV和非PFV眼之间的GRAE没有显着差异（年龄调整后的HR=1.20，95％CI：0.54-2.64，P=0.66）。
结论：观察到PFV白内障的视觉结果广泛，达到年龄正常VA的概率为10％。在PFV眼中存在发展青光眼相关不良事件的持续风险。
■我们研究了64例接受单侧手术的儿童的结局，与持续的胎儿血管系统相关的非创伤性白内障；48例左侧无晶状体，16例假晶状体。观察到持续性胎儿脉管系统白内障的视觉结果范围，达到年龄正常VA的概率为10％。无晶状体眼青光眼相关不良事件累积发生率为24%，这与没有持续性胎儿脉管系统的对照组相似。
方法：使用每年从医疗记录中收集的儿童白内障登记数据进行临床队列研究。
方法：64名13岁以下儿童，接受单侧手术，包括与PFV相关的非创伤性白内障。估计了5年随访时年龄正常视力（VA）和VA优于20/200的比例。计算5年的并发症和额外手术的累积发生率。从我们的注册表中比较了单侧PFV和单侧非PFV白内障的结果。
结果：64只眼中的48只眼术后无晶状体（手术时的中位年龄为2个月，范围1-13)和16是假晶状体(29个月，范围2到92)。总的来说,42只眼睛中的4只（10％，95%CI：3%-23%）达到年龄正常视力。VA优于20/200在17个(59%，95%CI39%-76%)单侧无晶状体PFV眼和44(43%，95%CI32%-54%)单侧非PFV无晶状体眼(年龄校正OR=1.90;95%CI:0.81-4.50;P=0.14)。无晶状体PFV眼最常见的并发症是青光眼相关不良事件（GRAE）（累积发生率24%，95%CI：9%-37%）。在晶状体切除术中年龄≤1岁的无晶状体参与者中，PFV和非PFV眼之间的GRAE没有显着差异（年龄调整后的HR=1.20，95％CI：0.54-2.64，P=0.66）。
结论：观察到PFV白内障的视觉结果广泛，达到年龄正常VA的概率为10％。在PFV眼中存在发展青光眼相关不良事件的持续风险。
■我们研究了64例接受单侧手术的儿童的结局，与持续的胎儿血管系统相关的非创伤性白内障；48例左侧无晶状体，16例假晶状体。观察到持续性胎儿脉管系统白内障的视觉结果范围，达到年龄正常VA的概率为10％。无晶状体眼青光眼相关不良事件累积发生率为24%，这与没有持续性胎儿脉管系统的对照组相似。
