Abstract：
Vitamin K2 (menaquinone, VK2, MK) is an essential lipid-soluble vitamin that plays critical roles in inhibiting cell ferroptosis, improving blood clotting, and preventing osteoporosis. The increased global demand for VK2 has inspired interest in novel production strategies. In this review, various novel metabolic regulation strategies, including static and dynamic metabolic regulation, are summarized and discussed. Furthermore, the advantages and disadvantages of both strategies are analyzed in-depth to highlight the bottlenecks facing microbial VK2 production on an industrial scale. Finally, advanced metabolic engineering biotechnology for future microbial VK2 production will also be discussed. In summary, this review provides in-depth information and offers an outlook on metabolic engineering strategies for VK2 production.
摘要：
维生素K2（甲基萘醌，VK2，MK）是一种必需的脂溶性维生素，在抑制细胞铁性凋亡中起关键作用，改善血液凝固，预防骨质疏松症。全球对VK2需求的增加激发了人们对新生产策略的兴趣。在这次审查中,各种新颖的代谢调节策略，包括静态和动态代谢调节，进行了总结和讨论。此外，深入分析了两种策略的优缺点，以突出工业规模的微生物VK2生产面临的瓶颈。最后,还将讨论用于未来微生物VK2生产的高级代谢工程生物技术。总之,这篇综述提供了深入的信息，并对VK2生产的代谢工程策略进行了展望。
