PDF(Pubmed)
Abstract：
Accurately identifying the peripheral pain generator in patients with chronic pain remains a major challenge for modern medicine. Millions of patients around the world suffer endlessly from difficult-to-manage debilitating pain because of very limited diagnostic tests and a paucity of pain therapies. To help these patients, we have developed a novel clinical molecular imaging approach, and, in its early stages, it has been shown to accurately identify the exact site of pain generation using an imaging biomarker for the sigma-1 receptor and positron emission tomography/magnetic resonance imaging. We hope the description of the work in this article can help others begin their own pain imaging programs at their respective institutions.
摘要：
准确识别慢性疼痛患者的外周疼痛发生器仍然是现代医学的主要挑战。由于非常有限的诊断测试和缺乏疼痛治疗，世界各地有数百万患者无休止地遭受难以管理的衰弱性疼痛。为了帮助这些病人，我们开发了一种新的临床分子成像方法，and,在其早期阶段，使用sigma-1受体的成像生物标志物和正电子发射断层扫描/磁共振成像,该方法已被证明可以准确识别疼痛发生的确切部位.我们希望本文中对工作的描述可以帮助其他人在各自的机构中开始自己的疼痛成像计划。
