Abstract：
Significance: Burns result in irretrievable cell damage, which can occur upon exposure to hot surfaces, liquids, gases, ultraviolet or ionizing radiation, and through friction. Standard of care in burn management involves protecting the patient, limiting burn progression, and achieving wound closure. Negative pressure wound therapy (NPWT) and NPWT with instillation and dwell time (NPWTi-d) are two wound management options that have been shown to improve outcomes for burn patients in recent years. This work provides a general review of NPWT and NPWTi-d use in burn wound management. A literature search was performed using PubMed and Embase for peer-reviewed publications and conference abstracts written in English and reporting on burn management using NPWT and/or NPWTi-d from a single manufacturer between 2000 and 2021. All burn types were included. Recent Advances: Thirteen studies and 308 patients were available for assessment. Use of NPWT was reported in a majority of studies (n = 11). When conventional NPWT was applied, graft take of >90% was observed and consistent final wound closure was achieved. Two studies described NPWTi-d use for burn wound management. NPWTi-d use promoted granulation tissue development in burn wounds. Critical Issues: Limited high-level prospective evidence exists for use of NPWT and NPWTi-d in burn wound management. Future Directions: Available literature on the use of NPWT and/or NPWTi-d in burn care has reported improved outcomes in wound bed preparation, which can ultimately lead to final wound closure. The use of these modalities should be considered in management of burn care patients.
摘要：
意义：烧伤导致不可挽回的细胞损伤，这可能发生在暴露于热表面时，液体,气体,紫外线或电离辐射，通过摩擦。烧伤管理中的护理标准包括保护患者，限制烧伤进展，并实现伤口闭合。负压伤口治疗（NPWT）和具有滴注和停留时间的NPWT（NPWTi-d）是两种伤口管理选择，近年来已被证明可以改善烧伤患者的预后。这项工作提供了NPWT和NPWTi-d在烧伤伤口管理中的一般回顾。使用PubMed和Embase进行文献检索，以获取英文撰写的同行评审出版物和会议摘要，并在2000年至2021年之间使用单个制造商的NPWT和/或NPWTi-d报告烧伤管理。包括所有烧伤类型。最新进展：13项研究和308例患者可用于评估。在大多数研究中报道了NPWT的使用(n=11)。当应用常规NPWT时，观察到>90%的移植物取出,并且实现一致的最终伤口闭合。两项研究描述了NPWTi-d用于烧伤伤口管理。NPWTi-d使用促进烧伤创面肉芽组织发育。关键问题：关于NPWT和NPWTi-d在烧伤伤口处理中的使用，存在有限的高级前瞻性证据。未来方向：关于NPWT和/或NPWTi-d在烧伤护理中使用的现有文献报道了伤口床准备的改善结果，最终可以导致最终的伤口闭合。在烧伤护理患者的管理中应考虑使用这些方式。
