PDF(Pubmed)
Abstract：
BACKGROUND: Encapsulated papillary carcinoma (EPC) is a rare subset of breast carcinoma accounting for 0.5% to 2.0% of all patients with breast cancer and occuring mostly in postmenopausal women. It is even rarer in male breast cancer, and male EPC has only been reported in few cases. EPC has a distinctive histological pattern and a better prognosis compared with other types of breast carcinoma. Compared to the previously reported EPC cases, the lesion was unusually cystic made the diagnosis challenging. Accordingly, herein, we describe a rare case of EPC was unusually cystic in an elder male breast, associated with ductal carcinoma in situ (DCIS), along with an indepth literature discussion, and then to improve our understanding more about this uncommon tumor and further to provide more experience to treat this disease.
METHODS: A 73-year-old man noticed a slowly enlarging mass in the right breast 1 year ago and sought medical attention. The patient presented with a right breast mass of 1-year duration and bloody nipple discharge in the first couple of days. The medical history was unremarkable.
METHODS: Physical examination, an elastic hard, smooth and movable 4-cm lesion was palpated below the right papilla. On the sonography, a well-defined predominantly cystic-solid tumor of 3.6 × 2.3 cm was confirmed. Postoperative pathological and immunohistochemical examinations of the surgical specimens revealed a final diagnosis of breast EPC with DCIS.
METHODS: The patient underwent surgery. A diagnosis of \"a little papillary neoplasm of the breast with epithelial atypia and hypertrophy in the fibrous cystic wall\" was made by the frozen section. Further, total mastectomy was performed.
RESULTS: The operation was successful. Then the male patient recovered completely, did not require any additional treatment and continued to do well on postsurgical mammary surgical clinic visits. The patient had been followed-up regularly for 2 years after surgery; he did not experience any complications and remained disease-free.
METHODS: A 73-year-old man noticed a slowly enlarging mass in the right breast 1 year ago and sought medical attention. The patient presented with a right breast mass of 1-year duration and bloody nipple discharge in the first couple of days. The medical history was unremarkable.
METHODS: Physical examination, an elastic hard, smooth and movable 4-cm lesion was palpated below the right papilla. On the sonography, a well-defined predominantly cystic-solid tumor of 3.6 × 2.3 cm was confirmed. Postoperative pathological and immunohistochemical examinations of the surgical specimens revealed a final diagnosis of breast EPC with DCIS.
METHODS: The patient underwent surgery. A diagnosis of \"a little papillary neoplasm of the breast with epithelial atypia and hypertrophy in the fibrous cystic wall\" was made by the frozen section. Further, total mastectomy was performed.
RESULTS: The operation was successful. Then the male patient recovered completely, did not require any additional treatment and continued to do well on postsurgical mammary surgical clinic visits. The patient had been followed-up regularly for 2 years after surgery; he did not experience any complications and remained disease-free.
摘要：
背景：包膜乳头状癌（EPC）是一种罕见的乳腺癌，占所有乳腺癌患者的0.5％至2.0％，主要发生在绝经后妇女中。在男性乳腺癌中更罕见，男性EPC仅在少数病例中报告。与其他类型的乳腺癌相比，EPC具有独特的组织学模式和更好的预后。与先前报告的EPC病例相比，病变是异常的囊性，这使得诊断具有挑战性。因此，在这里，我们描述了一个罕见的EPC病例，在老年男性乳房中异常囊性，与导管原位癌（DCIS）相关，伴随着深入的文学讨论，然后提高我们对这种罕见肿瘤的认识，并进一步提供更多的经验来治疗这种疾病。
方法：一名73岁的男子1年前注意到右乳房有一个缓慢增大的肿块，于是求医。该患者在头几天内出现1年的右乳房肿块和流血的乳头溢液。病史并不明显。
方法：体格检查，一个有弹性的坚硬，右侧乳头下方触诊光滑且可移动的4厘米病变。在超声波检查中，一个明确的主要为3.6×2.3cm的囊实性肿瘤被证实。手术标本的术后病理和免疫组织化学检查显示，最终诊断为乳腺EPC伴DCIS。
方法：患者接受了手术。冷冻切片诊断为“乳腺小乳头状肿瘤，纤维囊壁上皮异型和肥大”。Further,进行了全乳房切除术.
结果：手术成功。然后男患者完全康复,不需要任何额外的治疗，并且在术后乳腺外科门诊就诊时继续做得很好。该患者在手术后2年内定期随访;他没有出现任何并发症并且保持无病。
方法：一名73岁的男子1年前注意到右乳房有一个缓慢增大的肿块，于是求医。该患者在头几天内出现1年的右乳房肿块和流血的乳头溢液。病史并不明显。
方法：体格检查，一个有弹性的坚硬，右侧乳头下方触诊光滑且可移动的4厘米病变。在超声波检查中，一个明确的主要为3.6×2.3cm的囊实性肿瘤被证实。手术标本的术后病理和免疫组织化学检查显示，最终诊断为乳腺EPC伴DCIS。
方法：患者接受了手术。冷冻切片诊断为“乳腺小乳头状肿瘤，纤维囊壁上皮异型和肥大”。Further,进行了全乳房切除术.
结果：手术成功。然后男患者完全康复,不需要任何额外的治疗，并且在术后乳腺外科门诊就诊时继续做得很好。该患者在手术后2年内定期随访;他没有出现任何并发症并且保持无病。
