Abstract：
Bioprosthetic Heart Valves (BHVs) are widely used in clinical practice, showing promising outcomes. Computational modeling offers a valuable tool for quantitatively characterizing BHVs. To ensure the accuracy of computational models, it is crucial to consider precise leaflet properties, including mechanical properties and density. Bovine pericardium (BP) serves as a common material for BHV leaflets. Previous computational studies often assume BP density to approximate that of water or blood. Given that BP leaflets undergo various treatments, such as tissue fixation and anti-calcification, this study aims to measure the density of BP used in BHVs and assess its impact on leaflet stress distribution.
Eight square BP samples were laser cut from Edwards BP patches and their density was determined. Specimen weight was measured using an A&D Analytical Balance, while volume was assessed through high-resolution imaging. Additionally, finite element models resembling a BHV, like the Carpentier-Edwards PERIMOUNT Magna, were constructed in ABAQUS.
The average density of the BP samples was found to be 1,410 kg/m3. During the acceleration phase of a cardiac cycle, the maximum stress reached 1.89 MPa for a density of 1,410 kg/m3 and 2.47 MPa for a density of 1,000 kg/m3 (a 30.7% difference). In the deceleration phase, the maximum stress reached 713 kPa and 669 kPa, respectively.
Leaflet stress distribution and motion in BHVs are influenced by density variations. Establishing an accurate density value for BHV leaflets is imperative for enhancing the computational models, which can ultimately contribute to improved BHV design and outcomes.
Eight square BP samples were laser cut from Edwards BP patches and their density was determined. Specimen weight was measured using an A&D Analytical Balance, while volume was assessed through high-resolution imaging. Additionally, finite element models resembling a BHV, like the Carpentier-Edwards PERIMOUNT Magna, were constructed in ABAQUS.
The average density of the BP samples was found to be 1,410 kg/m3. During the acceleration phase of a cardiac cycle, the maximum stress reached 1.89 MPa for a density of 1,410 kg/m3 and 2.47 MPa for a density of 1,000 kg/m3 (a 30.7% difference). In the deceleration phase, the maximum stress reached 713 kPa and 669 kPa, respectively.
Leaflet stress distribution and motion in BHVs are influenced by density variations. Establishing an accurate density value for BHV leaflets is imperative for enhancing the computational models, which can ultimately contribute to improved BHV design and outcomes.
摘要：
目的：生物心脏瓣膜（BHVs）在临床实践中被广泛使用，显示出有希望的结果。计算建模为定量表征BHV提供了有价值的工具。为了确保计算模型的准确性，考虑精确的小叶特性至关重要，包括机械性能和密度。牛心包（BP）是BHV小叶的常用材料。以前的计算研究通常假设BP密度接近水或血液的密度。鉴于BP小叶经过各种治疗，如组织固定和抗钙化，本研究旨在测量BHV中使用的BP密度，并评估其对小叶应力分布的影响。
方法：从EdwardsBP贴片上激光切下八个正方形BP样品，并测定其密度。使用A&D分析天平测量试样重量，而通过高分辨率成像评估体积.此外,类似于BHV的有限元模型，就像Carpentier-EdwardsPerimountMagna,在ABAQUS建造。
结果:发现BP样品的平均密度为1,410kg/m3。在心动周期的加速阶段,密度为1,410kg/m3时的最大应力达到1.89MPa，密度为1,000kg/m3时的最大应力达到2.47MPa（差异为30.7％）。在减速阶段,最大应力达到713kPa和669kPa，分别。
结论：BHV中的小叶应力分布和运动受密度变化的影响。建立BHV小叶的准确密度值对于增强计算模型至关重要。这最终有助于改进BHV设计和结果。
方法：从EdwardsBP贴片上激光切下八个正方形BP样品，并测定其密度。使用A&D分析天平测量试样重量，而通过高分辨率成像评估体积.此外,类似于BHV的有限元模型，就像Carpentier-EdwardsPerimountMagna,在ABAQUS建造。
结果:发现BP样品的平均密度为1,410kg/m3。在心动周期的加速阶段,密度为1,410kg/m3时的最大应力达到1.89MPa，密度为1,000kg/m3时的最大应力达到2.47MPa（差异为30.7％）。在减速阶段,最大应力达到713kPa和669kPa，分别。
结论：BHV中的小叶应力分布和运动受密度变化的影响。建立BHV小叶的准确密度值对于增强计算模型至关重要。这最终有助于改进BHV设计和结果。
