关键词: autoimmune disease biopsie biopsy bulla bulle bullous disease derme dermis epidermis lesion lésion maladie auto-immune maladie bulleuse pemphigoid pemphigoïde pemphigus épiderme

Mesh : Humans Pemphigus / diagnosis pathology Pemphigoid, Bullous / diagnosis pathology Autoimmune Diseases / diagnosis pathology Skin Diseases, Vesiculobullous / pathology Autoantibodies

来  源:   DOI:10.1016/j.soin.2023.09.003

Abstract:
Autoimmune bullous diseases are disorders in which the immune system mistakenly attacks certain molecules that act as \"glue\" in the various layers of the skin, leading to the formation of bullae or vesicles. A bulla is a liquid-containing lesion over five millimeters in size on the skin or mucous membranes. It forms due to a loss of cohesion between the epidermis and dermis, or between keratinocytes within the epidermis. Diagnosis is based on biopsies, which show the presence of autoantibodies and the depth of skin detachment. A blood test can be used to identify circulating autoantibodies.
摘要:
自身免疫性大疱性疾病是免疫系统错误地攻击某些分子的疾病,这些分子在皮肤的各个层中充当“胶水”,导致大疱或囊泡的形成。大疱是皮肤或粘膜上尺寸超过5毫米的含液体的病变。它是由于表皮和真皮之间的凝聚力丧失而形成的,或表皮内的角质形成细胞之间。诊断是基于活检,显示自身抗体的存在和皮肤脱离的深度。血液测试可用于鉴定循环自身抗体。
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