PDF(Pubmed)
Abstract：
UNASSIGNED: Malnutrition commonly occurs in patients undergoing maintenance hemodialysis. Early detection of malnutrition could allow early interventions to prevent later complications. At present, there are not many biomarkers with high predictive value of end-stage kidney disease (ESKD)-related malnutrition, especially for early malnutrition in hemodialysis patients, which needs more in-depth research. Therefore, we performed a cross-sectional study on 97 patients to identify biomarkers for malnutrition in hemodialysis patients.
UNASSIGNED: 7-point subjective global assessment (SGA) was applied to evaluate the nutritional status of patients on hemodialysis. Serum levels of growth differentiation factor 15 (GDF15), albumin, pre-albumin, c-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), hemoglobin, low density lipoprotein-cholesterol, and high density lipoprotein-cholesterol were detected before hemodialysis. Logistic analysis and linear regression were used to analyze the association between GDF15 levels and the SGA score after adjustment for basic characteristics and laboratory findings.
UNASSIGNED: Among the 97 patients on hemodialysis, 51 had malnutrition (SGA < 6). There was no difference between the malnourished and well nourished (SGA ≥ 6) groups for dialysis duration, cholesterol, CRP, TNF-α, and hemoglobin. The malnutrition group had significantly lower grip strength (p < 0.05). GDF15 levels correlated negatively with the SGA score after adjustment for possible confounding factors [rho (male) = -0.312, rho(female)= -0.437;P(male) = 0.0181, P(female) = 0.005], and might contribute to the malnutritional status, the AUCs of GDF15 for malnutrition was 0.697 (p = 0.011) in male and 0.828 (p < 0.001) in female.
UNASSIGNED: GDF15 is associated with malnutrition according to the SGA score in patients with ESKD on hemodialysis, suggesting that GDF15 might be involved in the pathogenesis of malnutrition patients with ESKD in this setting. Furthermore, GDF15 is likely to be a potential diagnostic biomarker for malnutrition according to the SGA score.
UNASSIGNED: 7-point subjective global assessment (SGA) was applied to evaluate the nutritional status of patients on hemodialysis. Serum levels of growth differentiation factor 15 (GDF15), albumin, pre-albumin, c-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), hemoglobin, low density lipoprotein-cholesterol, and high density lipoprotein-cholesterol were detected before hemodialysis. Logistic analysis and linear regression were used to analyze the association between GDF15 levels and the SGA score after adjustment for basic characteristics and laboratory findings.
UNASSIGNED: Among the 97 patients on hemodialysis, 51 had malnutrition (SGA < 6). There was no difference between the malnourished and well nourished (SGA ≥ 6) groups for dialysis duration, cholesterol, CRP, TNF-α, and hemoglobin. The malnutrition group had significantly lower grip strength (p < 0.05). GDF15 levels correlated negatively with the SGA score after adjustment for possible confounding factors [rho (male) = -0.312, rho(female)= -0.437;P(male) = 0.0181, P(female) = 0.005], and might contribute to the malnutritional status, the AUCs of GDF15 for malnutrition was 0.697 (p = 0.011) in male and 0.828 (p < 0.001) in female.
UNASSIGNED: GDF15 is associated with malnutrition according to the SGA score in patients with ESKD on hemodialysis, suggesting that GDF15 might be involved in the pathogenesis of malnutrition patients with ESKD in this setting. Furthermore, GDF15 is likely to be a potential diagnostic biomarker for malnutrition according to the SGA score.
摘要：
■营养不良通常发生在接受维持性血液透析的患者中。早期发现营养不良可以进行早期干预以预防后期并发症。目前,对终末期肾病（ESKD）相关的营养不良具有高预测价值的生物标志物并不多，尤其是血液透析患者的早期营养不良，这需要更深入的研究。因此,我们对97例患者进行了横断面研究,以确定血液透析患者营养不良的生物标志物.
■7点主观整体评估（SGA）用于评估血液透析患者的营养状况。血清生长分化因子15(GDF15)水平,白蛋白,前白蛋白,C反应蛋白(CRP),肿瘤坏死因子α（TNF-α），血红蛋白,低密度脂蛋白-胆固醇，血液透析前检测高密度脂蛋白胆固醇。在校正基本特征和实验室检查结果后，采用Logistic分析和线性回归分析GDF15水平与SGA评分之间的关联。
■在97名血液透析患者中，51人营养不良(SGA<6)。营养不良和营养良好（SGA≥6）组的透析时间没有差异，胆固醇,CRP,TNF-α,和血红蛋白。营养不良组的握力显著降低(p<0.05)。校正可能的混杂因素后，GDF15水平与SGA评分呈负相关[rho（男性）=-0.312，rho（女性）=-0.437；P（男性）=0.0181，P（女性）=0.005]，并可能导致营养不良，男性GDF15营养不良的AUC为0.697(p=0.011),女性为0.828(p<0.001)。
■根据血液透析ESKD患者的SGA评分，GDF15与营养不良相关，提示GDF15可能参与了这种情况下ESKD营养不良患者的发病机制。此外，根据SGA评分，GDF15可能是营养不良的潜在诊断生物标志物。
■7点主观整体评估（SGA）用于评估血液透析患者的营养状况。血清生长分化因子15(GDF15)水平,白蛋白,前白蛋白,C反应蛋白(CRP),肿瘤坏死因子α（TNF-α），血红蛋白,低密度脂蛋白-胆固醇，血液透析前检测高密度脂蛋白胆固醇。在校正基本特征和实验室检查结果后，采用Logistic分析和线性回归分析GDF15水平与SGA评分之间的关联。
■在97名血液透析患者中，51人营养不良(SGA<6)。营养不良和营养良好（SGA≥6）组的透析时间没有差异，胆固醇,CRP,TNF-α,和血红蛋白。营养不良组的握力显著降低(p<0.05)。校正可能的混杂因素后，GDF15水平与SGA评分呈负相关[rho（男性）=-0.312，rho（女性）=-0.437；P（男性）=0.0181，P（女性）=0.005]，并可能导致营养不良，男性GDF15营养不良的AUC为0.697(p=0.011),女性为0.828(p<0.001)。
■根据血液透析ESKD患者的SGA评分，GDF15与营养不良相关，提示GDF15可能参与了这种情况下ESKD营养不良患者的发病机制。此外，根据SGA评分，GDF15可能是营养不良的潜在诊断生物标志物。
