PDF(Pubmed)
Abstract：
This case report discusses the diagnosis and management of late-onset systemic lupus erythematosus (SLE) in an elderly patient. Systemic lupus erythematosus is an autoimmune disease that affects several organs. Sex differences in incidence, especially among women in their childbearing years, have been linked to estrogen fluctuations. This study focuses on an 87-year-old male who initially presented with anorexia, a history of heart failure, pancytopenia, and elevated antinuclear antibodies. His symptoms were initially attributed to heart failure and pneumonia. However, further evaluation led to the suspicion of immune-mediated vasculitis. Treatment with prednisolone improved his condition; however, a recurrent decrease in food intake and increased inflammation prompted the consideration of late-onset SLE. The diagnosis was supported by laboratory results, including antinuclear antibodies and complement levels, in accordance with the diagnostic criteria. This case highlights the challenges in diagnosing late-onset SLE owing to its overlap with other conditions and emphasizes the importance of a multidisciplinary approach for accurate diagnosis and treatment. Early recognition and intervention are crucial for managing late-onset SLE, even in elderly patients, to prevent multiple organ failure and improve outcomes.
摘要：
本病例报告讨论了老年患者迟发性系统性红斑狼疮（SLE）的诊断和治疗。系统性红斑狼疮是一种影响多个器官的自身免疫性疾病。发病率的性别差异，尤其是在育龄妇女中，与雌激素波动有关.这项研究的重点是一名87岁的男性，他最初患有厌食症，有心力衰竭史,全血细胞减少症,抗核抗体升高.他的症状最初归因于心力衰竭和肺炎。然而,进一步评估导致怀疑免疫介导性血管炎.用泼尼松龙治疗改善了他的病情；然而，食物摄入的反复减少和炎症的增加促使人们考虑迟发性SLE.诊断得到了实验室结果的支持，包括抗核抗体和补体水平,符合诊断标准。该病例强调了由于与其他疾病重叠而诊断迟发性SLE的挑战，并强调了多学科方法对准确诊断和治疗的重要性。早期识别和干预对于管理迟发性SLE至关重要。即使是老年患者，预防多器官衰竭并改善预后。
