Abstract：
Recent events have raised concerns about the outbreak of a pandemic by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An infection caused by a virus can provoke an inflammatory reaction, which can result in severe lung damage, failure of several organs, and death. The unique genetic makeup of each individual may be a component in the development of each of these responses. In this context, genetic variants of the genes linked to the invasion of the virus into the host\'s body can be analyzed. Various elements have a function in viral entry. ACE2 is used by SARS-CoV-2 as a receptor to enter the cell. TMPRSS2 is then responsible for cutting the virus into its components. In addition, lung damage occurs when there is an imbalance between ACE1 and ACE2. Another component that plays a significant role in virus penetration is called IFITM3, which is created as a reaction to interferon. This protein prevents viruses in the Coronaviridae family from entering cells. This study aimed to analyze DNA polymorphisms in the ACE2, ACE1, TMPRSS2, and IFITM3 genes. Findings showed certain polymorphisms appear to be associated with the severity of the disease, including respiratory, coronary, and neurological disorders. The results also indicated that certain polymorphisms were protective against this virus. Varying populations have a different frequency of high-risk polymorphisms, so different treatment and preventative techniques must be implemented. Additional population studies should be conducted in this region to reduce the incidence of COVID-19-related morbidity and mortality.
摘要：
最近的事件引起了人们对严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）爆发大流行的担忧。由病毒引起的感染会引起炎症反应，会导致严重的肺损伤，几个器官衰竭，和死亡。每个个体的独特遗传组成可能是这些反应中的每一个的发展的组成部分。在这种情况下，可以分析与病毒侵入宿主体内有关的基因的遗传变异。各种元件在病毒进入中具有功能。ACE2被SARS-CoV-2用作进入细胞的受体。然后TMPRSS2负责将病毒切割成其组分。此外,当ACE1和ACE2不平衡时，就会发生肺损伤。另一种在病毒渗透中起重要作用的成分称为IFITM3，它是作为对干扰素的反应而产生的。这种蛋白质防止冠状病毒科中的病毒进入细胞。本研究旨在分析ACE2，ACE1，TMPRSS2和IFITM3基因的DNA多态性。研究结果表明，某些多态性似乎与疾病的严重程度有关，包括呼吸,冠状动脉,和神经系统疾病。结果还表明某些多态性对该病毒具有保护性。不同的人群具有不同的高风险多态性频率，因此，必须实施不同的治疗和预防技术。应在该地区进行其他人群研究，以降低COVID-19相关发病率和死亡率。
