PDF(Pubmed)
Abstract：
BACKGROUND: Hematogenous tumor spread of malignant meningiomas occurs very rarely but is associated with very poor prognosis.
METHODS: We report an unusual case of a patient with a malignant meningioma who developed multiple metastases in bones, lungs and liver after initial complete resection of the primary tumor. After partial hepatic resection, specimens were histologically analyzed, and a complete loss of E-cadherin adhesion molecules was found. No oncogenic target mutations were found. The patient received a combination of conventional radiotherapy and peptide receptor radionuclide therapy (PRRT). Due to aggressive tumor behavior and rapid spread of metastases, the patient deceased after initiation of treatment.
CONCLUSIONS: E-cadherin downregulation is associated with a higher probability of tumor invasion and distant metastasis formation in malignant meningioma. Up to now, the efficacy of systemic therapy, including PRRT, is very limited in malignant meningioma patients.
METHODS: We report an unusual case of a patient with a malignant meningioma who developed multiple metastases in bones, lungs and liver after initial complete resection of the primary tumor. After partial hepatic resection, specimens were histologically analyzed, and a complete loss of E-cadherin adhesion molecules was found. No oncogenic target mutations were found. The patient received a combination of conventional radiotherapy and peptide receptor radionuclide therapy (PRRT). Due to aggressive tumor behavior and rapid spread of metastases, the patient deceased after initiation of treatment.
CONCLUSIONS: E-cadherin downregulation is associated with a higher probability of tumor invasion and distant metastasis formation in malignant meningioma. Up to now, the efficacy of systemic therapy, including PRRT, is very limited in malignant meningioma patients.
摘要：
背景：恶性脑膜瘤的血源性肿瘤扩散很少发生，但预后极差。
方法：我们报告了一例罕见的恶性脑膜瘤患者，该患者在骨骼中发生了多发性转移，最初完全切除原发肿瘤后的肺和肝脏。肝部分切除后,标本进行组织学分析，并发现E-cadherin粘附分子完全丧失。未发现致癌靶突变。患者接受了常规放疗和肽受体放射性核素治疗（PRRT）的组合。由于侵袭性肿瘤行为和转移的快速扩散，患者在开始治疗后死亡。
结论：E-cadherin下调与恶性脑膜瘤中肿瘤侵袭和远处转移形成的可能性更高相关。到目前为止,全身治疗的疗效，包括PRRT,在恶性脑膜瘤患者中非常有限。
方法：我们报告了一例罕见的恶性脑膜瘤患者，该患者在骨骼中发生了多发性转移，最初完全切除原发肿瘤后的肺和肝脏。肝部分切除后,标本进行组织学分析，并发现E-cadherin粘附分子完全丧失。未发现致癌靶突变。患者接受了常规放疗和肽受体放射性核素治疗（PRRT）的组合。由于侵袭性肿瘤行为和转移的快速扩散，患者在开始治疗后死亡。
结论：E-cadherin下调与恶性脑膜瘤中肿瘤侵袭和远处转移形成的可能性更高相关。到目前为止,全身治疗的疗效，包括PRRT,在恶性脑膜瘤患者中非常有限。
