METHODS: We report an unusual case of a patient with a malignant meningioma who developed multiple metastases in bones, lungs and liver after initial complete resection of the primary tumor. After partial hepatic resection, specimens were histologically analyzed, and a complete loss of E-cadherin adhesion molecules was found. No oncogenic target mutations were found. The patient received a combination of conventional radiotherapy and peptide receptor radionuclide therapy (PRRT). Due to aggressive tumor behavior and rapid spread of metastases, the patient deceased after initiation of treatment.
CONCLUSIONS: E-cadherin downregulation is associated with a higher probability of tumor invasion and distant metastasis formation in malignant meningioma. Up to now, the efficacy of systemic therapy, including PRRT, is very limited in malignant meningioma patients.
方法:我们报告了一例罕见的恶性脑膜瘤患者,该患者在骨骼中发生了多发性转移,最初完全切除原发肿瘤后的肺和肝脏。肝部分切除后,标本进行组织学分析,并发现E-cadherin粘附分子完全丧失。未发现致癌靶突变。患者接受了常规放疗和肽受体放射性核素治疗(PRRT)的组合。由于侵袭性肿瘤行为和转移的快速扩散,患者在开始治疗后死亡。
结论:E-cadherin下调与恶性脑膜瘤中肿瘤侵袭和远处转移形成的可能性更高相关。到目前为止,全身治疗的疗效,包括PRRT,在恶性脑膜瘤患者中非常有限。