%0 Case Reports
%T Complete loss of E-cadherin expression in a rare case of metastatic malignant meningioma: a case report.
%A Lisowski D
%A Hartrampf PE
%A Hasenauer N
%A Nickl V
%A Monoranu CM
%A Tamihardja J
%J BMC Neurol
%V 23
%N 1
%D 2023 Nov 4
%M 37925427
%F 2.903
%R 10.1186/s12883-023-03450-w
%X <B>BACKGROUND: </B>Hematogenous tumor spread of malignant meningiomas occurs very rarely but is associated with very poor prognosis.<BR><B>METHODS: </B>We report an unusual case of a patient with a malignant meningioma who developed multiple metastases in bones, lungs and liver after initial complete resection of the primary tumor. After partial hepatic resection, specimens were histologically analyzed, and a complete loss of E-cadherin adhesion molecules was found. No oncogenic target mutations were found. The patient received a combination of conventional radiotherapy and peptide receptor radionuclide therapy (PRRT). Due to aggressive tumor behavior and rapid spread of metastases, the patient deceased after initiation of treatment.<BR><B>CONCLUSIONS: </B>E-cadherin downregulation is associated with a higher probability of tumor invasion and distant metastasis formation in malignant meningioma. Up to now, the efficacy of systemic therapy, including PRRT, is very limited in malignant meningioma patients.