Abstract：
The network meta-analysis (NMA) investigated the efficacy of six food supplements, namely glutamine, arginine, lactoferrin, prebiotics, synbiotics, and probiotics, in preventing necrotizing enterocolitis in premature infants.
MEDLINE, Embase, and Cochrane Library were searched. Randomized controlled trials comparing different food supplements for premature infants were included.
Probiotics (OR, 0.47; 95% CrI, 0.33-0.63), arginine (OR, 0.38; 95% CrI, 0.14-0.98), glutamine (OR, 0.30; 95% CrI, 0.079-0.90), and synbiotics (OR, 0.13; 95% CrI, 0.037-0.37). were associated with a decreased incidence of NEC. Only probiotics (OR, 0.81; 95% CrI, 0.69-0.95) and lactoferrin (OR, 0.74; 95% CrI, 0.54-0.92) achieved lower risk of sepsis. Probiotics (OR, 0.58; 95% CrI, 0.40-0.79), prebiotics (OR, 0.23; 95% CrI, 0.043-0.86), and synbiotics (OR, 0.15; 95% CrI, 0.035-0.50) were associated with lower odds of mortality. Probiotics (MD, -2.3; 95% CrI: -3.7- -0.63) appeared to have earlier age of attainment of full feeding.
Based on this NMA, probiotics and synbiotics had the potential to be the top two preferable food supplements.
MEDLINE, Embase, and Cochrane Library were searched. Randomized controlled trials comparing different food supplements for premature infants were included.
Probiotics (OR, 0.47; 95% CrI, 0.33-0.63), arginine (OR, 0.38; 95% CrI, 0.14-0.98), glutamine (OR, 0.30; 95% CrI, 0.079-0.90), and synbiotics (OR, 0.13; 95% CrI, 0.037-0.37). were associated with a decreased incidence of NEC. Only probiotics (OR, 0.81; 95% CrI, 0.69-0.95) and lactoferrin (OR, 0.74; 95% CrI, 0.54-0.92) achieved lower risk of sepsis. Probiotics (OR, 0.58; 95% CrI, 0.40-0.79), prebiotics (OR, 0.23; 95% CrI, 0.043-0.86), and synbiotics (OR, 0.15; 95% CrI, 0.035-0.50) were associated with lower odds of mortality. Probiotics (MD, -2.3; 95% CrI: -3.7- -0.63) appeared to have earlier age of attainment of full feeding.
Based on this NMA, probiotics and synbiotics had the potential to be the top two preferable food supplements.
摘要：
背景：网络荟萃分析（NMA）调查了六种食品补充剂的功效，即谷氨酰胺，精氨酸乳铁蛋白,益生元,合生元,和益生菌，预防早产儿坏死性小肠结肠炎。
方法：MEDLINE，Embase,搜索了Cochrane图书馆.包括比较早产儿不同食品补充剂的随机对照试验。
结果：益生菌（或，0.47;95%CrI,0.33-0.63)，精氨酸(OR，0.38;95%CrI,0.14-0.98),谷氨酰胺(OR，0.30;95%CrI,0.079-0.90),和合生元(或，0.13;95%CrI,0.037-0.37）。与NEC发生率降低有关。仅益生菌（或，0.81;95%CrI,0.69-0.95)和乳铁蛋白(OR，0.74;95%CrI,0.54-0.92）降低了脓毒症的风险。益生菌（或，0.58;95%CrI,0.40-0.79),益生元（或，0.23;95%CrI,0.043-0.86),和合生元(或，0.15;95%CrI,0.035-0.50）与较低的死亡率相关。益生菌（MD，-2.3；95％CrI：-3.7--0.63）似乎具有较早的完全喂养年龄。
结论：基于此NMA，益生菌和合生元有可能成为最受欢迎的两种食品补充剂。
方法：MEDLINE，Embase,搜索了Cochrane图书馆.包括比较早产儿不同食品补充剂的随机对照试验。
结果：益生菌（或，0.47;95%CrI,0.33-0.63)，精氨酸(OR，0.38;95%CrI,0.14-0.98),谷氨酰胺(OR，0.30;95%CrI,0.079-0.90),和合生元(或，0.13;95%CrI,0.037-0.37）。与NEC发生率降低有关。仅益生菌（或，0.81;95%CrI,0.69-0.95)和乳铁蛋白(OR，0.74;95%CrI,0.54-0.92）降低了脓毒症的风险。益生菌（或，0.58;95%CrI,0.40-0.79),益生元（或，0.23;95%CrI,0.043-0.86),和合生元(或，0.15;95%CrI,0.035-0.50）与较低的死亡率相关。益生菌（MD，-2.3；95％CrI：-3.7--0.63）似乎具有较早的完全喂养年龄。
结论：基于此NMA，益生菌和合生元有可能成为最受欢迎的两种食品补充剂。
