MEDLINE, Embase, and Cochrane Library were searched. Randomized controlled trials comparing different food supplements for premature infants were included.
Probiotics (OR, 0.47; 95% CrI, 0.33-0.63), arginine (OR, 0.38; 95% CrI, 0.14-0.98), glutamine (OR, 0.30; 95% CrI, 0.079-0.90), and synbiotics (OR, 0.13; 95% CrI, 0.037-0.37). were associated with a decreased incidence of NEC. Only probiotics (OR, 0.81; 95% CrI, 0.69-0.95) and lactoferrin (OR, 0.74; 95% CrI, 0.54-0.92) achieved lower risk of sepsis. Probiotics (OR, 0.58; 95% CrI, 0.40-0.79), prebiotics (OR, 0.23; 95% CrI, 0.043-0.86), and synbiotics (OR, 0.15; 95% CrI, 0.035-0.50) were associated with lower odds of mortality. Probiotics (MD, -2.3; 95% CrI: -3.7- -0.63) appeared to have earlier age of attainment of full feeding.
Based on this NMA, probiotics and synbiotics had the potential to be the top two preferable food supplements.
方法:MEDLINE,Embase,搜索了Cochrane图书馆.包括比较早产儿不同食品补充剂的随机对照试验。
结果:益生菌(或,0.47;95%CrI,0.33-0.63),精氨酸(OR,0.38;95%CrI,0.14-0.98),谷氨酰胺(OR,0.30;95%CrI,0.079-0.90),和合生元(或,0.13;95%CrI,0.037-0.37)。与NEC发生率降低有关。仅益生菌(或,0.81;95%CrI,0.69-0.95)和乳铁蛋白(OR,0.74;95%CrI,0.54-0.92)降低了脓毒症的风险。益生菌(或,0.58;95%CrI,0.40-0.79),益生元(或,0.23;95%CrI,0.043-0.86),和合生元(或,0.15;95%CrI,0.035-0.50)与较低的死亡率相关。益生菌(MD,-2.3;95%CrI:-3.7--0.63)似乎具有较早的完全喂养年龄。
结论:基于此NMA,益生菌和合生元有可能成为最受欢迎的两种食品补充剂。