Abstract：
To explore possible associations between modifiable lifestyle factors and health-related quality of life (HRQoL) in endometrial carcinoma survivors by assessing differences in HRQoL between survivors meeting and not meeting the World Health Organization\'s (WHO) recommendations regarding physical activity, BMI, and smoking.
This was a cross-sectional population-based study in women having undergone surgery for assumed early-stage endometrial carcinoma. Thresholds for clinical importance based on the EORTC QoL working group were used to interpret scores. Effect size (ES) was interpreted as small (d = 0.2-0.49), medium (d = 0.5-0.8), and large (d > 0.8).
In total, 1200 evaluable women were included. Meeting physical activity recommendations and BMI <25 kg/m2 was associated with significantly better global health status, (ES) = 0.18 and ES = -0.11, respectively. On multivariate analysis, women meeting physical activity recommendations had significantly higher scores on physical- (ES = 0.31), role- (ES = 0.15), and social functioning (ES = 0.15), and lower levels of fatigue (ES = -0.16), pain (ES = -0.10), and appetite loss (ES = -0.15) (all p < 0.05) compared to non-meeting survivors. Participants with BMI ≥25 kg/m2 had lower scores for social functioning (ES = -0.10), and higher levels of pain (ES = 0.13) and dyspnea (ES = 0.12) (all p < 0.05) compared to those with BMI <25 kg/m2. Smokers had lower scores for emotional functioning (ES = -0.09) and higher levels of diarrhea (ES = 0.10) (all p < 0.05) compared to non-smokers.
Meeting WHO recommendations for modifiable life-style factors is associated with better HRQoL among endometrial carcinoma survivors: Being sufficiently physical active and having a BMI <25 kg/m2 are significantly associated with better self-reported global health status. All modifiable factors are associated with better functioning, and reduced symptom-burden.
This was a cross-sectional population-based study in women having undergone surgery for assumed early-stage endometrial carcinoma. Thresholds for clinical importance based on the EORTC QoL working group were used to interpret scores. Effect size (ES) was interpreted as small (d = 0.2-0.49), medium (d = 0.5-0.8), and large (d > 0.8).
In total, 1200 evaluable women were included. Meeting physical activity recommendations and BMI <25 kg/m2 was associated with significantly better global health status, (ES) = 0.18 and ES = -0.11, respectively. On multivariate analysis, women meeting physical activity recommendations had significantly higher scores on physical- (ES = 0.31), role- (ES = 0.15), and social functioning (ES = 0.15), and lower levels of fatigue (ES = -0.16), pain (ES = -0.10), and appetite loss (ES = -0.15) (all p < 0.05) compared to non-meeting survivors. Participants with BMI ≥25 kg/m2 had lower scores for social functioning (ES = -0.10), and higher levels of pain (ES = 0.13) and dyspnea (ES = 0.12) (all p < 0.05) compared to those with BMI <25 kg/m2. Smokers had lower scores for emotional functioning (ES = -0.09) and higher levels of diarrhea (ES = 0.10) (all p < 0.05) compared to non-smokers.
Meeting WHO recommendations for modifiable life-style factors is associated with better HRQoL among endometrial carcinoma survivors: Being sufficiently physical active and having a BMI <25 kg/m2 are significantly associated with better self-reported global health status. All modifiable factors are associated with better functioning, and reduced symptom-burden.
摘要：
目的：探讨子宫内膜癌幸存者可改变的生活方式因素与健康相关生活质量（HRQoL）之间的可能关联，方法是评估参加世界卫生组织（WHO）关于体力活动的建议的幸存者之间HRQoL的差异。BMI,和吸烟。
方法：这是一项基于人群的横断面研究，研究对象是接受手术治疗的早期子宫内膜癌妇女。使用基于EORTCQoL工作组的临床重要性阈值来解释分数。效应大小(ES)被解释为小(d=0.2-0.49)，中等（d=0.5-0.8），和大（d>0.8）。
结果：总计，包括1200名可评价的妇女。满足身体活动建议和BMI<25kg/m2与显著改善的全球健康状况相关。(ES)分别=0.18和ES=-0.11。在多变量分析中，符合身体活动建议的女性在身体上的得分明显更高（ES=0.31），角色-(ES=0.15)，和社会功能(ES=0.15)，和较低的疲劳水平（ES=-0.16），疼痛（ES=-0.10），和食欲减退（ES=-0.15）（所有p<0.05）相比，非会议幸存者。BMI≥25kg/m2的参与者的社会功能得分较低（ES=-0.10），与BMI<25kg/m2的患者相比，疼痛（ES=0.13）和呼吸困难（ES=0.12）的水平更高（均p<0.05）。与非吸烟者相比，吸烟者的情绪功能得分较低（ES=-0.09），腹泻水平较高（ES=0.10）（所有p<0.05）。
结论：符合WHO关于可改变的生活方式因素的建议与子宫内膜癌幸存者中更好的HRQoL相关：足够的体力活动和BMI<25kg/m2与更好的自我报告的全球健康状况显著相关。所有可改变的因素都与更好的功能有关，减轻症状负担。
方法：这是一项基于人群的横断面研究，研究对象是接受手术治疗的早期子宫内膜癌妇女。使用基于EORTCQoL工作组的临床重要性阈值来解释分数。效应大小(ES)被解释为小(d=0.2-0.49)，中等（d=0.5-0.8），和大（d>0.8）。
结果：总计，包括1200名可评价的妇女。满足身体活动建议和BMI<25kg/m2与显著改善的全球健康状况相关。(ES)分别=0.18和ES=-0.11。在多变量分析中，符合身体活动建议的女性在身体上的得分明显更高（ES=0.31），角色-(ES=0.15)，和社会功能(ES=0.15)，和较低的疲劳水平（ES=-0.16），疼痛（ES=-0.10），和食欲减退（ES=-0.15）（所有p<0.05）相比，非会议幸存者。BMI≥25kg/m2的参与者的社会功能得分较低（ES=-0.10），与BMI<25kg/m2的患者相比，疼痛（ES=0.13）和呼吸困难（ES=0.12）的水平更高（均p<0.05）。与非吸烟者相比，吸烟者的情绪功能得分较低（ES=-0.09），腹泻水平较高（ES=0.10）（所有p<0.05）。
结论：符合WHO关于可改变的生活方式因素的建议与子宫内膜癌幸存者中更好的HRQoL相关：足够的体力活动和BMI<25kg/m2与更好的自我报告的全球健康状况显著相关。所有可改变的因素都与更好的功能有关，减轻症状负担。
