This was a cross-sectional population-based study in women having undergone surgery for assumed early-stage endometrial carcinoma. Thresholds for clinical importance based on the EORTC QoL working group were used to interpret scores. Effect size (ES) was interpreted as small (d = 0.2-0.49), medium (d = 0.5-0.8), and large (d > 0.8).
In total, 1200 evaluable women were included. Meeting physical activity recommendations and BMI <25 kg/m2 was associated with significantly better global health status, (ES) = 0.18 and ES = -0.11, respectively. On multivariate analysis, women meeting physical activity recommendations had significantly higher scores on physical- (ES = 0.31), role- (ES = 0.15), and social functioning (ES = 0.15), and lower levels of fatigue (ES = -0.16), pain (ES = -0.10), and appetite loss (ES = -0.15) (all p < 0.05) compared to non-meeting survivors. Participants with BMI ≥25 kg/m2 had lower scores for social functioning (ES = -0.10), and higher levels of pain (ES = 0.13) and dyspnea (ES = 0.12) (all p < 0.05) compared to those with BMI <25 kg/m2. Smokers had lower scores for emotional functioning (ES = -0.09) and higher levels of diarrhea (ES = 0.10) (all p < 0.05) compared to non-smokers.
Meeting WHO recommendations for modifiable life-style factors is associated with better HRQoL among endometrial carcinoma survivors: Being sufficiently physical active and having a BMI <25 kg/m2 are significantly associated with better self-reported global health status. All modifiable factors are associated with better functioning, and reduced symptom-burden.
方法:这是一项基于人群的横断面研究,研究对象是接受手术治疗的早期子宫内膜癌妇女。使用基于EORTCQoL工作组的临床重要性阈值来解释分数。效应大小(ES)被解释为小(d=0.2-0.49),中等(d=0.5-0.8),和大(d>0.8)。
结果:总计,包括1200名可评价的妇女。满足身体活动建议和BMI<25kg/m2与显著改善的全球健康状况相关。(ES)分别=0.18和ES=-0.11。在多变量分析中,符合身体活动建议的女性在身体上的得分明显更高(ES=0.31),角色-(ES=0.15),和社会功能(ES=0.15),和较低的疲劳水平(ES=-0.16),疼痛(ES=-0.10),和食欲减退(ES=-0.15)(所有p<0.05)相比,非会议幸存者。BMI≥25kg/m2的参与者的社会功能得分较低(ES=-0.10),与BMI<25kg/m2的患者相比,疼痛(ES=0.13)和呼吸困难(ES=0.12)的水平更高(均p<0.05)。与非吸烟者相比,吸烟者的情绪功能得分较低(ES=-0.09),腹泻水平较高(ES=0.10)(所有p<0.05)。
结论:符合WHO关于可改变的生活方式因素的建议与子宫内膜癌幸存者中更好的HRQoL相关:足够的体力活动和BMI<25kg/m2与更好的自我报告的全球健康状况显著相关。所有可改变的因素都与更好的功能有关,减轻症状负担。