Abstract：
The quantification of blood loss in a severe trauma patient allows prognostic quantification and the engagement of adapted therapeutic means. The Advanced Trauma Life Support classification of hemorrhagic shock, based in part on hemodynamic parameters, could be improved. The search for reproducible and non-invasive parameters closely correlated with blood depletion is a necessity. An experimental model of controlled hemorrhagic shock allowed us to obtain hemodynamic and echocardiographic measurements during controlled blood spoliation. The primary aim was to demonstrate the correlation between the Shock Index (SI) and blood depletion volume (BDV) during the hemorrhagic phase of an experimental model of controlled hemorrhagic shock in piglets. The secondary aim was to study the correlations between blood pressure (BP) values and BDV, SI and cardiac output (CO), and pulse pressure (PP) and stroke volume during the same phase.
We analyzed data from 66 anesthetized and ventilated piglets that underwent blood spoliation at 2 mL.kg-1.min-1 until a mean arterial pressure (MAP) of 40 mmHg was achieved. During this bleeding phase, hemodynamic and echocardiographic measurements were performed regularly.
The correlation coefficient between the SI and BDV was 0.70 (CI 95%, [0.64; 0.75]; p < 0.01), whereas between MAP and BDV, the correlation coefficient was -0.47 (CI 95%, [-0.55; -0.38]; p < 0.01). Correlation coefficient between SI and CO and between PP and stroke volume were - 0.45 (CI 95%, [-0.53; -0.37], p < 0.01) and 0.62 (CI 95%, [0.56; 0.67]; p < 0.01), respectively.
In a controlled hemorrhagic shock model in piglets, the correlation between SI and BDV seemed strong.
We analyzed data from 66 anesthetized and ventilated piglets that underwent blood spoliation at 2 mL.kg-1.min-1 until a mean arterial pressure (MAP) of 40 mmHg was achieved. During this bleeding phase, hemodynamic and echocardiographic measurements were performed regularly.
The correlation coefficient between the SI and BDV was 0.70 (CI 95%, [0.64; 0.75]; p < 0.01), whereas between MAP and BDV, the correlation coefficient was -0.47 (CI 95%, [-0.55; -0.38]; p < 0.01). Correlation coefficient between SI and CO and between PP and stroke volume were - 0.45 (CI 95%, [-0.53; -0.37], p < 0.01) and 0.62 (CI 95%, [0.56; 0.67]; p < 0.01), respectively.
In a controlled hemorrhagic shock model in piglets, the correlation between SI and BDV seemed strong.
摘要：
背景：严重创伤患者失血的定量允许预后定量和适应的治疗手段的参与。失血性休克的高级创伤生命支持分类，部分基于血液动力学参数，可以改进。搜索与血液消耗密切相关的可重复和非侵入性参数是必要的。受控失血性休克的实验模型使我们能够在受控失血过程中获得血液动力学和超声心动图测量结果。主要目的是证明仔猪受控失血性休克实验模型的出血期休克指数（SI）与血容量（BDV）之间的相关性。次要目的是研究血压（BP）值与BDV之间的相关性，SI和心输出量（CO），和脉冲压力（PP）和冲程容积在同一阶段。
方法：我们分析了66只麻醉和通气的仔猪的数据，这些仔猪接受了2mL的血液溶解。kg-1.min-1直到达到40mmHg的平均动脉压（MAP）。在这个出血阶段,定期进行血流动力学和超声心动图测量.
结果：SI和BDV之间的相关系数为0.70（CI95％，[0.64；0.75]；p<0.01)，而在MAP和BDV之间，相关系数为-0.47(CI95%，[-0.55;-0.38];p<0.01)。SI和CO之间以及PP和每搏量之间的相关系数为-0.45(CI95%，[-0.53;-0.37],p<0.01)和0.62(CI95%，[0.56；0.67]；p<0.01)，分别。
结论：在仔猪受控失血性休克模型中，SI和BDV之间的相关性似乎很强。
方法：我们分析了66只麻醉和通气的仔猪的数据，这些仔猪接受了2mL的血液溶解。kg-1.min-1直到达到40mmHg的平均动脉压（MAP）。在这个出血阶段,定期进行血流动力学和超声心动图测量.
结果：SI和BDV之间的相关系数为0.70（CI95％，[0.64；0.75]；p<0.01)，而在MAP和BDV之间，相关系数为-0.47(CI95%，[-0.55;-0.38];p<0.01)。SI和CO之间以及PP和每搏量之间的相关系数为-0.45(CI95%，[-0.53;-0.37],p<0.01)和0.62(CI95%，[0.56；0.67]；p<0.01)，分别。
结论：在仔猪受控失血性休克模型中，SI和BDV之间的相关性似乎很强。
