PDF(Pubmed)
Abstract：
We report the first case of monkeypox virus (MPXV) associated acute respiratory distress syndrome (ARDS). A 34-year-old French woman with no medical history was admitted to the intensive care unit (ICU) for fever, altered mental status, hypotension and hypoxaemia. She presented with a diffuse skin rash with vesiculopustular lesions involving the four limbs and perineal ulcers with a skin swab positive for MPXV. On day 2, the patient presented moderate ARDS requiring invasive mechanical ventilation. She also had pleural empyema due to Streptococcus pyogenes. MPXV PCR was positive in the bronchoalveolar lavage, the pleural effusion and the blood. The patient was treated with tecovirimat. Despite the treatment, she had persistent viraemia for at least ten days. The patient condition rapidly improved; she was weaned from mechanical ventilation on day 18 despite the persistence of radiological lung opacities. She fully recovered and was discharged home on day 38 after admission.
CONCLUSIONS: This is the first case of monkeypox virus associated ARDS in a young woman with no medical historyBiological follow-up showed disseminated MPXV and persistent viraemiaTecovirimat was well tolerated.
CONCLUSIONS: This is the first case of monkeypox virus associated ARDS in a young woman with no medical historyBiological follow-up showed disseminated MPXV and persistent viraemiaTecovirimat was well tolerated.
摘要：
我们报告了首例猴痘病毒（MPXV）相关的急性呼吸窘迫综合征（ARDS）。一名三十四岁无病史的法国女子因发烧入住重症监护病房(ICU),精神状态改变,低血压和低氧血症。她表现为弥漫性皮疹，伴有累及四肢的膀胱脓疱性病变和会阴溃疡，皮肤拭子对MPXV呈阳性。在第2天,患者出现需要有创机械通气的中度ARDS。她还患有化脓性链球菌引起的胸膜脓胸。MPXVPCR在支气管肺泡灌洗中呈阳性，胸腔积液和血液.该患者接受了tecovirimat治疗。尽管有治疗,她患有持续性病毒血症至少十天。患者病情迅速改善；尽管放射性肺混浊持续存在，但她在第18天停止了机械通气。她完全康复，入院后第38天出院。
结论：这是第一例猴痘病毒相关ARDS的病例，在一名没有病史的年轻女性中。生物学随访显示播散性MPXV和持续性病毒血症。
结论：这是第一例猴痘病毒相关ARDS的病例，在一名没有病史的年轻女性中。生物学随访显示播散性MPXV和持续性病毒血症。
