Abstract：
BACKGROUND: Chitosan (CS) is a polycationic polysaccharide comprising glucosamine and N-acetylglucosamine and constitutes a potential material for use in cartilage tissue engineering. Moreover, CS hydrogels are able to promote the expression of cartilage matrix components and reduce inflammatory and catabolic mediator production by chondrocytes. Although all the positive outcomes, no review has analyzed the effects of CS hydrogels on cartilage repair in animal models.
METHODS: This study aimed to review the literature to examine the effects of CS hydrogels on cartilage repair in experimental animal models. The search was done by the descriptors of the Medical Subject Headings (MeSH) defined below: \"Chitosan,\" \"hydrogel,\" \"cartilage repair,\" and \"in vivo.\" A total of 420 articles were retrieved from the databases Pubmed, Scopus, Embase, Lilacs, and Web of Science. After the eligibility analyses, this review reported 9 different papers from the beginning of 2002 through the middle of 2022.
RESULTS: It was found that cartilage repair was improved with the treatment of CS hydrogel, especially the one enriched with cells. In addition, CS hydrogel produced an upregulation of genes and proteins that act in the cartilage repair process, improving the biomechanical properties of gait..
CONCLUSIONS: In conclusion, CS hydrogels were able to stimulate tissue ingrowth and accelerate the process of cartilage repair in animal studies.
METHODS: This study aimed to review the literature to examine the effects of CS hydrogels on cartilage repair in experimental animal models. The search was done by the descriptors of the Medical Subject Headings (MeSH) defined below: \"Chitosan,\" \"hydrogel,\" \"cartilage repair,\" and \"in vivo.\" A total of 420 articles were retrieved from the databases Pubmed, Scopus, Embase, Lilacs, and Web of Science. After the eligibility analyses, this review reported 9 different papers from the beginning of 2002 through the middle of 2022.
RESULTS: It was found that cartilage repair was improved with the treatment of CS hydrogel, especially the one enriched with cells. In addition, CS hydrogel produced an upregulation of genes and proteins that act in the cartilage repair process, improving the biomechanical properties of gait..
CONCLUSIONS: In conclusion, CS hydrogels were able to stimulate tissue ingrowth and accelerate the process of cartilage repair in animal studies.
摘要：
背景:壳聚糖(CS)是包含葡糖胺和N-乙酰葡糖胺的聚阳离子多糖,并且构成用于软骨组织工程的潜在材料。此外，CS水凝胶能够促进软骨基质组分的表达并减少软骨细胞产生的炎症和分解代谢介质。虽然所有的积极成果，没有综述分析CS水凝胶对动物模型软骨修复的影响。
方法：本研究旨在回顾文献，以检查CS水凝胶在实验动物模型中对软骨修复的影响。通过以下定义的医学主题词（MeSH）的描述符进行搜索：“壳聚糖，“\”水凝胶，“\”软骨修复，\"和\"在体内。“从Pubmed数据库共检索到420篇文章，Scopus,Embase,丁香花,和WebofScience。在资格分析之后，这篇综述报道了从2002年初到2022年中期的9篇不同的论文.
结果：发现CS水凝胶治疗可改善软骨修复，尤其是富含细胞的那个。此外,CS水凝胶产生在软骨修复过程中起作用的基因和蛋白质的上调，提高步态的生物力学特性。
结论：结论：在动物研究中，CS水凝胶能够刺激组织向内生长并加速软骨修复过程。
方法：本研究旨在回顾文献，以检查CS水凝胶在实验动物模型中对软骨修复的影响。通过以下定义的医学主题词（MeSH）的描述符进行搜索：“壳聚糖，“\”水凝胶，“\”软骨修复，\"和\"在体内。“从Pubmed数据库共检索到420篇文章，Scopus,Embase,丁香花,和WebofScience。在资格分析之后，这篇综述报道了从2002年初到2022年中期的9篇不同的论文.
结果：发现CS水凝胶治疗可改善软骨修复，尤其是富含细胞的那个。此外,CS水凝胶产生在软骨修复过程中起作用的基因和蛋白质的上调，提高步态的生物力学特性。
结论：结论：在动物研究中，CS水凝胶能够刺激组织向内生长并加速软骨修复过程。
