UNASSIGNED: A total of 416 pediatric patients (≤ 14 years old) with brain tumors who underwent surgery were randomly assigned to the training (n = 333) and validation cohorts (n = 83). Based on the implementation of VP shunt, the training cohort was divided into the VP shunt group (n = 35) and the non-VP shunt group (n = 298). Univariate and multivariate logistic analyses were performed. A scoring system was developed based on clinical characteristics and operative data, and scores and corresponding risks were calculated.
UNASSIGNED: Age < 3 (p = 0.010, odds ratio [OR] = 3.162), blood loss (BL) (p = 0.005, OR = 1.300), midline tumor location (p < 0.001, OR = 5.750), preoperative hydrocephalus (p = 0.001, OR = 7.044), and total resection (p = 0.025, OR = 0.284) were identified as independent predictors. The area under the curve (AUC) of the scoring system was higher than those of age < 3, BL, midline tumor location, preoperative hydrocephalus, and total resection (0.859 vs. 0.598, 0.717, 0.725, 0.705, and 0.555, respectively; p < 0.001). Furthermore, the scoring system showed good performance in the validation cohort (AUC = 0.971). The cutoff value for predictive scores was 5.5 points, which categorized patients into low risk (0-5 points) and high risk (6-14 points) groups.
UNASSIGNED: Our scoring system, integrating age < 3, BL, midline tumor location, preoperative hydrocephalus, and total resection, provides a practical evaluation. Scores ranging from 6 to 14 points indicate high risk.
■共有416名接受手术治疗的脑肿瘤患儿(≤14岁)被随机分配到训练组(n=333)和验证组(n=83)。在实施VP分流的基础上,训练队列分为VP分流组(n=35)和非VP分流组(n=298).进行单变量和多变量逻辑分析。根据临床特征和手术数据开发了评分系统,并计算得分和相应的风险。
■年龄<3(p=0.010,比值比[OR]=3.162),失血量(BL)(p=0.005,OR=1.300),中线肿瘤位置(p<0.001,OR=5.750),术前脑积水(p=0.001,OR=7.044),和全切除(p=0.025,OR=0.284)被确定为独立预测因素。评分系统的曲线下面积(AUC)高于年龄<3,BL,中线肿瘤位置,术前脑积水,和全切除(0.859vs.分别为0.598、0.717、0.725、0.705和0.555;p<0.001)。此外,评分系统在验证队列中表现良好(AUC=0.971).预测分数的截止值为5.5分,将患者分为低风险(0-5分)和高风险(6-14分)组。
■我们的评分系统,积分年龄<3,BL,中线肿瘤位置,术前脑积水,和完全切除,提供了一个实用的评价。分数从6到14分表示高风险。