METHODS: This was a single-center prospective cohort study. ARMS was performed in GERD patients by an experienced endoscopist. The patients were required to undergo symptom assessment as well as endoscopic examination, high-resolution manometry (HRM), and impedance-pH monitoring before and after ARMS.
RESULTS: Twelve patients were enrolled. Follow-up was completed by all patients at 3 and 6 months, 11 patients at 1 year, and 8 patients at 2 years after ARMS, respectively. Symptom improvement was achieved in 66.7%, 75.0%, 72.7%, and 50.0% of the patients at 3 months, 6 months, 1 year, and 2 years after ARMS, respectively. Postoperative dysphagia was reported by 25.0%, 25.0%, 27.3%, and 25.0% of patients at 3 months, 6 months, 1 year, and 2 years after surgery, none of whom required additional invasive treatment. All patients with preoperative esophagitis healed after ARMS. For impedance-pH monitoring parameters, number of acidic reflux episodes and the proportion of patients with acid exposure time (AET) >4.0% decreased significantly after ARMS.
CONCLUSIONS: ARMS was safe and effective in Chinese GERD patients. The efficacy of ARMS was not short-term and remained evident throughout the 2-year follow-up. Further multicenter studies with larger sample sizes are needed to verify our findings.
方法:这是一项单中心前瞻性队列研究。由经验丰富的内镜医师对入选的GERD患者进行ARMS。这些患者需要接受症状评估和内窥镜检查,ARMS前后的高分辨率测压(HRM)和阻抗pH监测。
结果:共纳入12例患者,所有这些人都在3个月和6个月完成了随访,ARMS后1年11例,2年8例。3个月时症状改善的患者比例,6个月,1年,ARMS后2年为66.7%,75.0%,72.7%,分别为50.0%。手术后吞咽困难的报告为25.0%,25.0%,27.3%,25.0%的患者在3个月时,6个月,手术后1年和2年,没有人需要额外的侵入性治疗。所有术前食管炎患者均在ARMS后愈合。对于阻抗-pH监测参数,ARMS后,酸反流发作次数和酸暴露时间(AET)%>4.0%的患者比例显着降低。
结论:本研究证明ARMS对中国GERD患者是安全有效的。ARMS的疗效不是短期的,在本研究的2年随访期间仍然很明显。仍需要更多样本量的多中心研究来验证我们的发现。本文受版权保护。保留所有权利。