PDF(Pubmed)
Abstract：
BACKGROUND: Anticonvulsant drugs are one of the most common causes of delayed hypersensitivity reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). These reactions are more prevalent with aromatic anticonvulsant drugs such as phenytoin and carbamazepine. However, immediate hypersensitivity reactions such as urticaria, angioedema, and anaphylaxis with anticonvulsant drugs are rare. We describe a 51-year-old woman who developed spreading skin rashes on her wrists with urticaria and pruritus 24 h after receiving intravenous levetiracetam.
CONCLUSIONS: Clinicians should be aware of immediate hypersensitivity reactions with intravenous levetiracetam.
CONCLUSIONS: Clinicians should be aware of immediate hypersensitivity reactions with intravenous levetiracetam.
摘要：
背景：抗惊厥药物是迟发性超敏反应的最常见原因之一，如嗜酸性粒细胞增多和全身症状的药物反应（DRESS），史蒂文斯-约翰逊综合征（SJS），和中毒性表皮坏死松解症（TEN）。这些反应在苯妥英和卡马西平等芳香族抗惊厥药物中更为普遍。然而,即时超敏反应，如荨麻疹，血管性水肿,抗惊厥药物的过敏反应很少见。我们描述了一名51岁的妇女，在接受静脉注射左乙拉西坦后24小时，手腕上出现皮疹并伴有荨麻疹和瘙痒。
结论：临床医生应该意识到静脉注射左乙拉西坦的即时超敏反应。
结论：临床医生应该意识到静脉注射左乙拉西坦的即时超敏反应。
