Abstract：
Electrospinning is a versatile technique for fabricating polymeric fibers with diameters ranging from micro- to nanoscale, exhibiting multiple morphologies and arrangements. By combining silk fibroin (SF) with synthetic and/or natural polymers, electrospun materials with outstanding biological, chemical, electrical, physical, mechanical, and optical properties can be achieved, fulfilling the evolving biomedical demands. This review highlights the remarkable versatility of SF-derived electrospun materials, specifically focusing on their application in tissue regeneration (including cartilage, cornea, nerves, blood vessels, bones, and skin), disease treatment (such as cancer and diabetes), and the development of controlled drug delivery systems. Additionally, we explore the potential future trends in utilizing these nanofibrous materials for creating intelligent biomaterials, incorporating biosensors and wearable sensors for monitoring human health, and also discuss the bottlenecks for its widespread use. This comprehensive overview illuminates the significant impact and exciting prospects of SF-derived electrospun materials in advancing biomedical research and applications.
摘要：
静电纺丝是一种多功能技术，用于制造直径范围从微米到纳米级的聚合物纤维，表现出多种形态和排列。通过将丝素蛋白（SF）与合成和/或天然聚合物结合，具有出色生物学特性的静电纺材料，化学,电气,物理，机械,可以实现光学特性，满足不断发展的生物医学需求。这篇综述强调了SF衍生的静电纺丝材料的显着多功能性，特别关注它们在组织再生中的应用(包括软骨，角膜,神经,血管,骨头,和皮肤），疾病治疗（如癌症和糖尿病）以及受控药物递送系统的开发。此外,我们探索利用这些纳米纤维材料创造智能生物材料的潜在未来趋势，结合生物传感器和可穿戴传感器监测人体健康，并讨论了其广泛使用的瓶颈。这个全面的概述阐明了SF衍生的电纺材料在推进生物医学研究和应用方面的重大影响和令人兴奋的前景。
