Abstract：
Blueberries are rich in nutrients and (poly)phenols, popular with consumers, and a major agricultural crop with year-round availability supporting their use in food-based strategies to promote human health. Accumulating evidence indicates blueberry consumption has protective effects on cardiovascular health including vascular dysfunction (i.e., endothelial dysfunction and arterial stiffening). This narrative review synthesizes evidence on blueberries and vascular function and provides insight into underlying mechanisms with a focus on oxidative stress, inflammation, and gut microbiota. Evidence from animal studies supports beneficial impacts on vascular function. Human studies indicate acute and chronic blueberry consumption can improve endothelial function in healthy and at-risk populations and may modulate arterial stiffness, but that evidence is less certain. Results from cell, animal, and human studies suggest blueberry consumption improves vascular function through improving nitric oxide bioavailability, oxidative stress, and inflammation. Limited data in animals suggest the gut microbiome mediates beneficial effects of blueberries on vascular function; however, there is a paucity of studies evaluating the gut microbiome in humans. Translational evidence indicates anthocyanin metabolites mediate effects of blueberries on endothelial function, though this does not exclude potential synergistic and/or additive effects of other blueberry components. Further research is needed to establish the clinical efficacy of blueberries to improve vascular function in diverse human populations in a manner that provides mechanistic information. Translation of clinical research to the community/public should consider feasibility, social determinants of health, culture, community needs, assets, and desires, barriers, and drivers to consumption, among other factors to establish real-world impacts of blueberry consumption.
摘要：
蓝莓含有丰富的营养和（多）酚，深受消费者欢迎，和主要农作物，全年供应，支持将其用于以粮食为基础的战略，以促进人类健康。越来越多的证据表明，食用蓝莓对心血管健康有保护作用，包括血管功能障碍(即，内皮功能障碍和动脉硬化）。这篇叙述性综述综合了蓝莓和血管功能的证据，并提供了对氧化应激的潜在机制的见解。炎症,和肠道微生物群。来自动物研究的证据支持对血管功能的有益影响。人体研究表明，急性和慢性食用蓝莓可以改善健康和高危人群的内皮功能，并可能调节动脉僵硬度。但证据不太确定.来自细胞的结果，动物,人体研究表明，食用蓝莓可以通过提高一氧化氮的生物利用度来改善血管功能，氧化应激，和炎症。动物的有限数据表明，肠道微生物组介导蓝莓对血管功能的有益作用；然而，对人类肠道微生物组进行评估的研究很少。转化证据表明，花青素代谢产物介导蓝莓对内皮功能的影响，尽管这并不排除其他蓝莓成分的潜在协同和/或累加效应。需要进一步的研究来建立蓝莓的临床功效，以提供机制信息的方式改善不同人群的血管功能。临床研究向社区/公众的翻译应考虑可行性，健康的社会决定因素，文化,社区需求,资产，和欲望，障碍,以及消费的驱动因素，在其他因素中，确定蓝莓消费对现实世界的影响。
