PDF(Pubmed)
Abstract：
This review investigates the role of aneuploidy and chromosome instability (CIN) in the aging brain. Aneuploidy refers to an abnormal chromosomal count, deviating from the normal diploid set. It can manifest as either a deficiency or excess of chromosomes. CIN encompasses a broader range of chromosomal alterations, including aneuploidy as well as structural modifications in DNA. We provide an overview of the state-of-the-art methodologies utilized for studying aneuploidy and CIN in non-tumor somatic tissues devoid of clonally expanded populations of aneuploid cells.CIN and aneuploidy, well-established hallmarks of cancer cells, are also associated with the aging process. In non-transformed cells, aneuploidy can contribute to functional impairment and developmental disorders. Despite the importance of understanding the prevalence and specific consequences of aneuploidy and CIN in the aging brain, these aspects remain incompletely understood, emphasizing the need for further scientific investigations.This comprehensive review consolidates the present understanding, addresses discrepancies in the literature, and provides valuable insights for future research efforts.
摘要：
这篇综述研究了非整倍体和染色体不稳定性（CIN）在衰老大脑中的作用。非整倍体是指异常的染色体计数，偏离正常的二倍体集。它可以表现为染色体的缺乏或过量。CIN涵盖了更广泛的染色体改变，包括DNA的非整倍性和结构修饰。我们概述了用于研究无克隆扩增的非整倍体细胞群体的非肿瘤体细胞组织中的非整倍体和CIN的最新方法。CIN和非整倍性，癌细胞的公认标志，也与衰老过程有关。在非转化细胞中，非整倍体可导致功能障碍和发育障碍。尽管了解非整倍体和CIN在衰老大脑中的患病率和具体后果的重要性，这些方面仍然没有完全理解，强调需要进一步的科学研究。这次全面审查巩固了目前的理解，解决文献中的差异，并为未来的研究工作提供有价值的见解。
