PDF(Pubmed)
Abstract：
The aetiologic agent of COVID-19 is a novel coronavirus, SARS-CoV-2. Like other coronaviruses, it generally induces enteric and respiratory diseases in animals and humans. COVID-19 may be subclinical, and symptomatic, ranging from mild-to-severe disease. The spectrum of presentation is the result of several factors ranging from the inoculum size, inherent host susceptibility, possible cross-reacting circulating antibodies. Subclinical viral infections are associated with widespread community transmission and in some cases like Polio, herd immunity. An understanding of the biology and immune behavior in subclinical coronavirus disease 2019 (COVID-19) might be useful in the quest for vaccine development as well as the current control efforts against the COVID-19 pandemic. We carried out a narrative review of the available literature on the biology, etiopathogenesis, clinical manifestation of SARS-CoV-2 viral infection, focusing on our current understanding of the disease mechanisms and its clinical manifestation, and the host immune response to the infection. We also highlighted some of the research gaps regarding subclinical infection in COVID-19 and its potential application for vaccine development and other preventive efforts toward containing the current COVID-19 pandemic.
摘要：
COVID-19的病原体是一种新型冠状病毒，SARS-CoV-2.像其他冠状病毒一样，它通常会引起动物和人类的肠道和呼吸道疾病。COVID-19可能是亚临床的，和症状，从轻度到重度的疾病。呈现的范围是几个因素的结果，从接种物的大小，固有的宿主易感性，可能的交叉反应循环抗体。亚临床病毒感染与广泛的社区传播有关，在某些情况下，例如脊髓灰质炎，群体免疫力。对亚临床冠状病毒病2019（COVID-19）的生物学和免疫行为的了解可能有助于寻求疫苗开发以及当前针对COVID-19大流行的控制努力。我们对现有的生物学文献进行了叙述性回顾，病因，SARS-CoV-2病毒感染的临床表现，着眼于我们目前对疾病机制及其临床表现的理解，以及宿主对感染的免疫反应。我们还强调了一些关于COVID-19亚临床感染的研究空白，及其在疫苗开发和其他预防工作中的潜在应用，以遏制当前的COVID-19大流行。
