Abstract：
Numerous toxic substances are directly and indirectly discharged by humans into water bodies, causing distress to the organisms living on it. 6PPD, an amino antioxidant from tires reacts with ozone to form 6PPD-Q, which has garnered global attention due to its lethal nature to various organisms. This review aims to provide an understanding of the sources, transformation, and fate of 6PPD-Q in water and the current knowledge on its effects on aquatic organisms. Furthermore, we discuss research gaps pertaining to the mechanisms by which 6PPD-Q acts within fish bodies. Previous studies have demonstrated the ubiquitous presence of 6PPD-Q in the environment, including air, water, and soil. Moreover, this compound has shown high lethality to certain fish species while not affecting others. Toxicological studies have revealed its impact on the nervous system, intestinal barrier function, cardiac function, equilibrium loss, and oxidative stress in various fish species. Additionally, exposure to 6PPD-Q has led to organ injury, lipid accumulation, and cytokine production in C. elegans and mice. Despite studies elucidating the lethal dose and effects of 6PPD-Q in fish species, the underlying mechanisms behind these symptoms remain unclear. Future studies should prioritize investigating the mechanisms underlying the lethality of 6PPD-Q in fish species to gain a better understanding of its potential effects on different organisms.
摘要：
大量的有毒物质被人类直接和间接地排放到水体中,给生活在上面的生物带来痛苦。6PPD,来自轮胎的氨基抗氧化剂与臭氧反应形成6PPD-Q，由于其对各种生物的致命性，引起了全球的关注。这篇综述旨在了解来源，改造,6PPD-Q在水中的命运及其对水生生物影响的最新知识。此外，我们讨论了与6PPD-Q在鱼体内作用机制有关的研究空白。以前的研究已经证明了6PPD-Q在环境中的普遍存在，包括空气,水,和土壤。此外，这种化合物对某些鱼类显示出很高的杀伤力，而对其他鱼类没有影响。毒理学研究揭示了它对神经系统的影响，肠屏障功能,心功能,平衡损失，和各种鱼类的氧化应激。此外,暴露于6PPD-Q导致器官损伤，脂质积累，以及秀丽隐杆线虫和小鼠中细胞因子的产生。尽管有研究阐明了6PPD-Q在鱼类中的致死剂量和作用，这些症状背后的潜在机制尚不清楚.未来的研究应优先研究6PPD-Q在鱼类中的致死机制，以更好地了解其对不同生物的潜在影响。
