METHODS: Accumulated AGEs in the skin were assessed by non-invasive measurement of skin autofluorescence (SAF) inside the forearm. This retrospective study included individuals who underwent SAF measurements at Shujitsu University Community Pharmacy with or without a prescription from October 2019 to October 2021. Subsequently, the associations between SAF, calendar age, comorbidities, and blood test parameters were investigated.
RESULTS: SAF showed a positive correlation with calendar age for all enrolled participants; the correlation weakened for participants aged ≥50 years and plateaued for those aged ≥60 years. Furthermore, we observed a significant increase in SAF among all participants with comorbidities compared to those without comorbidities. By contrast, among participants aged ≥50 years, SAF did not show a significant association with comorbidities. However, SAF was significantly positively correlated with white blood cell (WBC) counts in these aged populations.
CONCLUSIONS: The non-invasive assessment of SAF holds promise in evaluating changes in the physical condition associated with WBC counts among older adults.
方法:通过前臂内部皮肤自发荧光(SAF)的非侵入性测量来评估皮肤中累积的AGEs。这项回顾性研究包括从2019年10月至2021年10月在舒松大学社区药房接受SAF测量的个体,无论有无处方。随后,苏丹武装部队之间的联系,日历年龄,合并症,和血液测试参数进行了调查。
结果:SAF与所有参与者的日历年龄呈正相关;年龄≥50岁的参与者的相关性减弱,年龄≥60岁的参与者的相关性趋于稳定。此外,我们观察到,与没有合并症的参与者相比,所有有合并症的参与者的SAF显著增加.相比之下,在≥50岁的参与者中,SAF与合并症没有显着关联。然而,在这些老年人群中,SAF与白细胞(WBC)计数呈显着正相关。
结论:SAF的非侵入性评估有望评估老年人与白细胞计数相关的身体状况变化。