PDF(Pubmed)
Abstract：
OBJECTIVE: Advanced glycation end products (AGEs) accumulate in the body with increasing age. However, their excessive accumulation may lead to various inflammatory and chronic diseases. While it is common for older adults to experience various comorbidities, there is a scarcity of published literature documenting the specific impact of ageing and comorbidities on AGEs in this population. The present study aimed to retrospectively evaluate the correlation among AGEs in the skin, calendar age, and comorbidities in older adults.
METHODS: Accumulated AGEs in the skin were assessed by non-invasive measurement of skin autofluorescence (SAF) inside the forearm. This retrospective study included individuals who underwent SAF measurements at Shujitsu University Community Pharmacy with or without a prescription from October 2019 to October 2021. Subsequently, the associations between SAF, calendar age, comorbidities, and blood test parameters were investigated.
RESULTS: SAF showed a positive correlation with calendar age for all enrolled participants; the correlation weakened for participants aged ≥50 years and plateaued for those aged ≥60 years. Furthermore, we observed a significant increase in SAF among all participants with comorbidities compared to those without comorbidities. By contrast, among participants aged ≥50 years, SAF did not show a significant association with comorbidities. However, SAF was significantly positively correlated with white blood cell (WBC) counts in these aged populations.
CONCLUSIONS: The non-invasive assessment of SAF holds promise in evaluating changes in the physical condition associated with WBC counts among older adults.
METHODS: Accumulated AGEs in the skin were assessed by non-invasive measurement of skin autofluorescence (SAF) inside the forearm. This retrospective study included individuals who underwent SAF measurements at Shujitsu University Community Pharmacy with or without a prescription from October 2019 to October 2021. Subsequently, the associations between SAF, calendar age, comorbidities, and blood test parameters were investigated.
RESULTS: SAF showed a positive correlation with calendar age for all enrolled participants; the correlation weakened for participants aged ≥50 years and plateaued for those aged ≥60 years. Furthermore, we observed a significant increase in SAF among all participants with comorbidities compared to those without comorbidities. By contrast, among participants aged ≥50 years, SAF did not show a significant association with comorbidities. However, SAF was significantly positively correlated with white blood cell (WBC) counts in these aged populations.
CONCLUSIONS: The non-invasive assessment of SAF holds promise in evaluating changes in the physical condition associated with WBC counts among older adults.
摘要：
目的：晚期糖基化终产物（AGEs）随着年龄的增长在体内积累。然而,它们的过度积累可能导致各种炎症和慢性疾病。虽然老年人经常经历各种合并症，在这一人群中,很少有发表文献记载衰老和合并症对AGEs的具体影响.本研究旨在回顾性评估皮肤中AGEs之间的相关性，日历年龄,和老年人的合并症。
方法：通过前臂内部皮肤自发荧光（SAF）的非侵入性测量来评估皮肤中累积的AGEs。这项回顾性研究包括从2019年10月至2021年10月在舒松大学社区药房接受SAF测量的个体，无论有无处方。随后，苏丹武装部队之间的联系，日历年龄,合并症,和血液测试参数进行了调查。
结果：SAF与所有参与者的日历年龄呈正相关；年龄≥50岁的参与者的相关性减弱，年龄≥60岁的参与者的相关性趋于稳定。此外，我们观察到,与没有合并症的参与者相比,所有有合并症的参与者的SAF显著增加.相比之下,在≥50岁的参与者中，SAF与合并症没有显着关联。然而,在这些老年人群中，SAF与白细胞（WBC）计数呈显着正相关。
结论：SAF的非侵入性评估有望评估老年人与白细胞计数相关的身体状况变化。
方法：通过前臂内部皮肤自发荧光（SAF）的非侵入性测量来评估皮肤中累积的AGEs。这项回顾性研究包括从2019年10月至2021年10月在舒松大学社区药房接受SAF测量的个体，无论有无处方。随后，苏丹武装部队之间的联系，日历年龄,合并症,和血液测试参数进行了调查。
结果：SAF与所有参与者的日历年龄呈正相关；年龄≥50岁的参与者的相关性减弱，年龄≥60岁的参与者的相关性趋于稳定。此外，我们观察到,与没有合并症的参与者相比,所有有合并症的参与者的SAF显著增加.相比之下,在≥50岁的参与者中，SAF与合并症没有显着关联。然而,在这些老年人群中，SAF与白细胞（WBC）计数呈显着正相关。
结论：SAF的非侵入性评估有望评估老年人与白细胞计数相关的身体状况变化。
