PDF(Pubmed)
Abstract：
Long-stranded noncoding RNAs (LncRNAs) are noncoding RNAs >200 nucleotides in length. Polycytidine binding protein 1 antisense LncRNA is abbreviated as LncRNA polycytosine binding protein 1 antisense1 (PCBP1-AS1). Since studies in recent years have revealed the importance of PCBP1-AS1 in human genetic analysis, it is an important member of the LncRNA family. Genetically engineered group analysis of PCBP1-AS1 regulates the progression of cancer in biology. Therefore, it may be an important RNA in the regulation of human cancer. This article summarizes the molecular mechanism and clinical role of PCBP1-AS1 in various tumor types. Taking \"PCBP1-AS1\" and \"cancer\" as keywords, this paper analyzed the relationship between PCBP1-AS1 and various tumors by searching PubMed and Geen Medical, and summarized the related regulatory mechanism of PCBP1-AS1. PCBP1-AS1 is a valuable tumor-associated LncRNA that plays different biological roles in different cancers. Overall, it can both promote and inhibit the development of cancer. For example, abnormally high expression in castration-resitant prostate cancer, hepatocellular carcinoma, cervical cancer, glioma, and colorectal cancer promotes the proliferation and progression of these cancers; in contrast, PCBP1-AS1 inhibits cancer proliferation, metastasis, invasion, and recurrence when highly expressed in vulvar squamous cell carcinoma, Hodgkin lymphoma, and lung adenocarcinoma. PCBP1-AS1 regulates the development of multiple tumors, and the specific mechanism needs to be further investigated, which may become a new tumor marker and potential therapeutic target.
摘要：
长链非编码RNA(LncRNA)是长度>200个核苷酸的非编码RNA。多聚胞苷结合蛋白1反义LncRNA缩写为LncRNA多聚胞嘧啶结合蛋白1反义1(PCBP1-AS1)。由于近年来的研究揭示了PCBP1-AS1在人类基因分析中的重要性，它是LncRNA家族的重要成员。PCBP1-AS1的基因工程组分析在生物学中调节癌症的进展。因此,它可能是调节人类癌症的重要RNA。本文就PCBP1-AS1在不同类型肿瘤中的分子机制及临床作用作一综述。以“PCBP1-AS1”和“癌症”为关键词，本文通过检索PubMed和GeenMedical,并总结了PCBP1-AS1的相关调控机制。PCBP1-AS1是一种有价值的肿瘤相关LncRNA，在不同的癌症中发挥不同的生物学作用。总的来说,它可以促进和抑制癌症的发展。例如,在去势-复发前列腺癌中异常高表达，肝细胞癌，宫颈癌,神经胶质瘤,结直肠癌促进这些癌症的增殖和进展；相比之下，PCBP1-AS1抑制癌症增殖，转移,入侵,在外阴鳞状细胞癌中高表达时复发，霍奇金淋巴瘤,和肺腺癌。PCBP1-AS1调节多种肿瘤的发展，具体机制有待进一步研究，可能成为新的肿瘤标志物和潜在的治疗靶点。
