PDF(Pubmed)
Abstract：
This thorough literature evaluation was prompted by significant research into the complex interactions between estrogen use and myocardial infarction (MI). Estrogen has fascinated researchers because of its possible cardioprotective benefits and its impact on cardiovascular health. In order to clarify the connection between estrogen use and the risk of MI, this review critically examines the body of prior evidence. This review focuses on estrogen and its pivotal role in cardiovascular health, concentrating on lipid metabolism, vasodilation, inflammation, and endothelial function. It examines contentious data about estrogen therapy\'s heart-protective effects, taking into account age, initiation timing, dosage, and dosage of administration. Genetic and epigenetic influences on MI risk among estrogen users highlight intricate, personalized estrogen effects. The conclusion summarizes the main findings and emphasizes the need for an all-encompassing strategy for initiating and managing estrogen medication. It is crucial to consider patient-specific traits and risk factors to successfully customize treatment regimens. This review sheds vital light on the potential directions for better cardiovascular treatment for postmenopausal women by shedding light on the complex link between estrogen use and myocardial infarction. The review also identifies research gaps and future objectives in this area, highlighting the demand for novel medicines and individualized strategies to improve cardiovascular outcomes.
摘要：
对雌激素使用与心肌梗塞（MI）之间复杂相互作用的大量研究促使了这种全面的文献评估。雌激素因其可能的心脏保护益处及其对心血管健康的影响而使研究人员着迷。为了阐明雌激素使用与MI风险之间的联系，这篇综述严格审查了先前的证据。本文综述了雌激素及其在心血管健康中的关键作用。专注于脂质代谢，血管舒张,炎症,和内皮功能。它检查了有关雌激素疗法的心脏保护作用的有争议的数据，考虑到年龄,启动定时,剂量,和给药剂量。雌激素使用者对MI风险的遗传和表观遗传影响突出了复杂，个性化的雌激素效果。结论总结了主要发现，并强调需要一种全面的策略来启动和管理雌激素药物。至关重要的是要考虑患者的特定特征和风险因素，以成功定制治疗方案。这篇综述通过阐明雌激素使用与心肌梗塞之间的复杂联系，为绝经后妇女更好的心血管治疗提供了重要的指导。审查还确定了该领域的研究差距和未来目标，强调对新药和个性化策略的需求，以改善心血管结局。
