Abstract：
BACKGROUND: Ameloblastic fibro-dentinoma is considered a rare, benign, mixed odontogenic tumor that occurs mainly in the posterior mandible in the 1st-2nd decade of life. Although the clinical behavior of Ameloblastic fibro-dentinoma is similar to that of ameloblastic fibroma, there is a debate about whether Ameloblastic fibro-dentinoma is a developing hamartomatous odontoma or a separate neoplastic odontogenic tumor like ameloblastic fibroma. However, it is important to understand the histopathogenesis of this rare tumor.
METHODS: A case report presenting an 11-year-old male child with a swelling in the posterior mandible. Radiographic examination revealed a multilocular lesion with mixed radiodensity related to the impacted lower left second premolar tooth. Incisional biopsy was done, and microscopic examination revealed cords and nests of odontogenic follicles lined by ameloblast-like cells and central stellate reticulum-like cells in the primitive ecto-mesenchymal stroma with areas of dentinoid material and osteodentin. The diagnosis was ameloblastic fibro-dentinoma. Surgical excision of the lesion was done, and the patient was followed up for 1 year without evidence of recurrence.
CONCLUSIONS: Reporting such a rare entity clarifies the debate about its nature and the importance of early diagnosis of lesions that are associated with unerupted teeth showing how it is effective in early management and prognosis.
METHODS: A case report presenting an 11-year-old male child with a swelling in the posterior mandible. Radiographic examination revealed a multilocular lesion with mixed radiodensity related to the impacted lower left second premolar tooth. Incisional biopsy was done, and microscopic examination revealed cords and nests of odontogenic follicles lined by ameloblast-like cells and central stellate reticulum-like cells in the primitive ecto-mesenchymal stroma with areas of dentinoid material and osteodentin. The diagnosis was ameloblastic fibro-dentinoma. Surgical excision of the lesion was done, and the patient was followed up for 1 year without evidence of recurrence.
CONCLUSIONS: Reporting such a rare entity clarifies the debate about its nature and the importance of early diagnosis of lesions that are associated with unerupted teeth showing how it is effective in early management and prognosis.
摘要：
背景：成釉细胞纤维性牙本质瘤被认为是一种罕见的，良性,混合牙源性肿瘤，主要发生在生命的第1-2个十年中的下颌骨后部。尽管成釉细胞纤维性牙本质瘤的临床行为与成釉细胞性纤维瘤相似，关于成釉细胞纤维性牙本质瘤是正在发展中的错构瘤性牙本质瘤还是像成釉细胞性纤维瘤一样的成釉细胞性牙本质瘤存在争议。然而,了解这种罕见肿瘤的组织病理学是很重要的。
方法：一例11岁男性儿童下颌骨后部肿胀的病例报告。影像学检查显示多房性病变，与受影响的左下第二前磨牙相关的放射密度混合。做了切开活检,显微镜检查显示，在原始的外间充质基质中，成釉细胞样细胞和中央星状网样细胞排列的牙源性卵泡的索和巢，并带有类牙质材料和骨凝蛋白。诊断为成釉细胞纤维性牙本质瘤。手术切除了病灶，患者随访1年,无复发证据.
结论：报道这种罕见的实体澄清了关于其性质和早期诊断与未萌出牙齿相关的病变的重要性的争论，表明其在早期治疗和预后中的有效性。
方法：一例11岁男性儿童下颌骨后部肿胀的病例报告。影像学检查显示多房性病变，与受影响的左下第二前磨牙相关的放射密度混合。做了切开活检,显微镜检查显示，在原始的外间充质基质中，成釉细胞样细胞和中央星状网样细胞排列的牙源性卵泡的索和巢，并带有类牙质材料和骨凝蛋白。诊断为成釉细胞纤维性牙本质瘤。手术切除了病灶，患者随访1年,无复发证据.
结论：报道这种罕见的实体澄清了关于其性质和早期诊断与未萌出牙齿相关的病变的重要性的争论，表明其在早期治疗和预后中的有效性。
