Serum Cytokine Changes in a Patient with Chronic Pulmonary Aspergillosis Overlapping with Allergic Bronchopulmonary Aspergillosis.

慢性肺曲霉病合并过敏性支气管肺曲霉病患者血清细胞因子变化 ： 一例。

• 影响指数: 1.282
• 发表时间: 2024 Jun 1
• 来源期刊: Intern Med
• DOI: 10.2169/internalmedicine.2234-23
• PMID: 37899245
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Tsukamoto Y,Ito Y,Obase Y,Takazono T,Nakada N,Ashizawa N,Hirayama T,Takeda K,Ide S,Iwanaga N,Tashiro M,Hosogaya N,Fukahori S,Fukushima C,Yanagihara K,Izumikawa K,Mukae H

关键词: IL-10; IL-33; allergic bronchopulmonary aspergillosis (ABPA); chronic pulmonary aspergillosis (CPA)

Mesh: Humans; Aspergillosis, Allergic Bronchopulmonary / blood drug therapy diagnosis complications; Pulmonary Aspergillosis / blood diagnosis drug therapy complications; Chronic Disease; Cytokines / blood; Voriconazole / therapeutic use; Antifungal Agents / therapeutic use; Male; Middle Aged

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are diseases caused by Aspergillus infection, and CPA can develop from ABPA in some cases. We herein report a patient with CPA overlapping with ABPA. Serum cytokine levels were evaluated at 4 time points: the ABPA diagnosis, CPA diagnosis, 6 months after the start of voriconazole (VRCZ), and 12 months after re-administration of VRCZ. Interleukin (IL)-13 levels decreased upon glucocorticoid treatment, whereas IL-25 and IL-33 levels decreased rapidly with the initiation of antifungals. Early antifungal therapy may be important to control disease progression and prevent CPA overlap.

摘要

过敏性支气管肺曲霉病（ABPA）和慢性肺曲霉病（CPA）是由曲霉感染引起的疾病，在某些情况下，注册会计师可以从ABPA开发。我们在此报告一名CPA与ABPA重叠的患者。在4个时间点评估血清细胞因子水平：ABPA诊断，CPA诊断,伏立康唑（VRCZ）开始后6个月，以及重新施用VRCZ后12个月。白细胞介素（IL）-13水平在糖皮质激素治疗后降低，而IL-25和IL-33水平随着抗真菌药的开始而迅速下降。早期抗真菌治疗对于控制疾病进展和预防CPA重叠可能很重要。