PDF(Pubmed)
Abstract：
Abdominal Aortic Aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. This study aimed to examine the potential association of the +276G/T and -420C>G polymorphisms in the resistin gene with AAA susceptibility and progression.
We performed a retrospective study involving AAA patients and healthy controls, assessing the distribution of the +276G/T and -420C>G genotypes in both groups. Hardy-Weinberg equilibrium was assessed for both polymorphisms. Logistic regression was used to explore the influence of these genotypes on AAA occurrence and progression, adjusting for relevant confounders.
The distribution of +276G/T polymorphism did not significantly differ between AAA patients and controls. Conversely, a significant difference was observed in the genotype distribution of -420C>G polymorphism between the two groups. The CC genotype and CC/CG genotypes of -420C>G polymorphism were found to be associated with an increased risk and progression of AAA.
The -420C>G polymorphism, particularly the CC genotype and CC/CG genotypes, might play a substantial role in AAA susceptibility and progression. The present findings underscore the need for further investigations to confirm these associations and fully elucidate the role of the resistin gene in AAA.
We performed a retrospective study involving AAA patients and healthy controls, assessing the distribution of the +276G/T and -420C>G genotypes in both groups. Hardy-Weinberg equilibrium was assessed for both polymorphisms. Logistic regression was used to explore the influence of these genotypes on AAA occurrence and progression, adjusting for relevant confounders.
The distribution of +276G/T polymorphism did not significantly differ between AAA patients and controls. Conversely, a significant difference was observed in the genotype distribution of -420C>G polymorphism between the two groups. The CC genotype and CC/CG genotypes of -420C>G polymorphism were found to be associated with an increased risk and progression of AAA.
The -420C>G polymorphism, particularly the CC genotype and CC/CG genotypes, might play a substantial role in AAA susceptibility and progression. The present findings underscore the need for further investigations to confirm these associations and fully elucidate the role of the resistin gene in AAA.
摘要：
目的：腹主动脉瘤（AAA）是一种具有遗传和环境危险因素的复杂疾病。本研究旨在研究抵抗素基因中+276G/T和-420C>G多态性与AAA易感性和进展的潜在关联。
方法：我们进行了一项涉及AAA患者和健康对照的回顾性研究，评估两组中+276G/T和-420C>G基因型的分布。评估了两种多态性的Hardy-Weinberg平衡。Logistic回归分析这些基因型对AAA发生和进展的影响。调整相关的混杂因素。
结果：+276G/T多态性的分布在AAA患者和对照组之间没有显著差异。相反，-420C>G多态性的基因型分布在两组之间观察到显着差异。发现-420C>G多态性的CC基因型和CC/CG基因型与AAA的风险增加和进展相关。
结论：-420C>G多态性，特别是CC基因型和CC/CG基因型，可能在AAA易感性和进展中起重要作用。本发现强调需要进一步研究以确认这些关联并充分阐明抵抗素基因在AAA中的作用。
方法：我们进行了一项涉及AAA患者和健康对照的回顾性研究，评估两组中+276G/T和-420C>G基因型的分布。评估了两种多态性的Hardy-Weinberg平衡。Logistic回归分析这些基因型对AAA发生和进展的影响。调整相关的混杂因素。
结果：+276G/T多态性的分布在AAA患者和对照组之间没有显著差异。相反，-420C>G多态性的基因型分布在两组之间观察到显着差异。发现-420C>G多态性的CC基因型和CC/CG基因型与AAA的风险增加和进展相关。
结论：-420C>G多态性，特别是CC基因型和CC/CG基因型，可能在AAA易感性和进展中起重要作用。本发现强调需要进一步研究以确认这些关联并充分阐明抵抗素基因在AAA中的作用。
