PDF(Pubmed)
Abstract：
Drug-induced pruritus triggers a desire to scratch, thereby diminishing one\'s quality of life. Certain instances of this phenomenon follow complex mechanisms of action that diverge from histamine-mediated pathways, known contributors to pruritus. However, investigations into the relationship between drugs and pruritus are limited. In this study, data mining techniques were employed to comprehensively analyze the characteristics of drugs linked to pruritus, using the FDA\'s Adverse Event Reporting System (FAERS) data. Reports linked to pruritus demonstrated noteworthy differences in gender, age, and weight when compared with non-pruritus cases. Among the leading candidates for drugs prompting pruritus were ophthalmic drugs, systemic antibacterials, contrast media, dermatological antifungals, and dermatological preparations. A principal component analysis showed that the second principal component served as an indicator for distinguishing between onsets at mucous membranes or the skin\'s surface. Additionally, the third principal component functioned as an indicator for categorizing administration methods as either invasive or noninvasive. Furthermore, a hierarchical cluster analysis conducted on these obtained principal components revealed the potential for classifying drugs based on the site of pruritus onset and the method of drug administration. These findings contribute to the development of targeted prevention and treatment strategies for avoiding pruritus in clinical practice.
摘要：
药物引起的瘙痒引发了抓挠的欲望，从而降低一个人的生活质量。这种现象的某些实例遵循与组胺介导途径不同的复杂作用机制，已知瘙痒的贡献者。然而,对药物与瘙痒之间关系的调查有限。在这项研究中,利用数据挖掘技术综合分析与瘙痒相关的药物的特点,使用FDA的不良事件报告系统(FAERS)数据。与瘙痒有关的报告显示了值得注意的性别差异，年龄,和体重与非瘙痒病例相比。促使瘙痒的药物的主要候选药物是眼科药物，全身抗菌药物,造影剂,皮肤病学抗真菌药，和皮肤病学制剂。主成分分析表明，第二主成分可作为区分粘膜或皮肤表面发作的指标。此外,第三主成分可作为将给药方法分类为侵入性或非侵入性的指标.此外，对这些获得的主成分进行的层次聚类分析揭示了根据瘙痒发作部位和给药方法对药物进行分类的潜力。这些发现有助于制定有针对性的预防和治疗策略，以避免临床实践中的瘙痒。
