PDF(Pubmed)
Abstract：
Chronic pain is an unpleasant experience associated with actual or potential tissue damage. Inflammatory pain alerts the body to inflammation and promotes healing; however, unresolved inflammation can lead to chronic pain. Conversely, neuropathic pain, due to somatosensory damage, can be a disease in itself. However, inflammation plays a considerable role in the progression of both types of pain. Resolvins, derived from omega-3 fatty acids, actively suppress pro-inflammatory mediators and aid in the resolution of inflammation. Resolvins alleviate various inflammatory and neuropathic pain models by reducing hypersensitivity and regulating inflammatory cytokines and glial activation in the spinal cord and dorsal root ganglia. Thus, resolvins are a promising alternative for pain management with the potential to reduce the side effects associated with conventional medications. Continued research is crucial to unlock the therapeutic potential of resolvins and integrate them into effective clinical pain management strategies. This review aimed to evaluate the literature surrounding the resolvins in inflammatory and neuropathic pain.
摘要：
慢性疼痛是与实际或潜在的组织损伤相关的不愉快经历。炎性疼痛提醒身体炎症并促进愈合;然而，未解决的炎症可导致慢性疼痛。相反，神经性疼痛,由于体感损伤，它本身就是一种疾病。然而,炎症在两种类型的疼痛的进展中起着相当大的作用。Resolvins,来自omega-3脂肪酸，积极抑制促炎介质和帮助解决炎症。消退蛋白通过减少超敏反应和调节脊髓和背根神经节中的炎性细胞因子和神经胶质激活来缓解各种炎性和神经性疼痛模型。因此，resolvins是疼痛管理的有希望的替代方案，有可能减少与常规药物相关的副作用。持续的研究对于释放resolvins的治疗潜力并将其整合到有效的临床疼痛管理策略中至关重要。这篇综述旨在评估围绕炎性和神经性疼痛中的消退素的文献。
