Abstract：
OBJECTIVE: This study aimed to describe the optical and topographic changes after manual superficial keratectomy (MSK) for Salzmann nodular degeneration.
METHODS: This was a descriptive, retrospective study. All patients with a clinical diagnosis of Salzmann nodular degeneration were examined at the Cornea Service of the Instituto Clínico Quirúrgico de Oftalmología (ICQO), Bilbao, Spain, and treated with MSK after presenting ocular discomfort and/or decreased visual acuity. The clinical characteristics (including anterior segment optical coherence tomography and Pentacam topography), treatment regimens, surgical procedures, and outcomes were recorded. Descriptive statistics were constructed using mean ± SD, minimum, maximum, and median. The Shapiro-Wilk normality test was used. The Student t test was used to determine significance.
RESULTS: Ten eyes of 9 patients were included in this study: 6 patients (66.6%) were female and 3 were male (33.3%). The mean age was 62.2 years, and the follow-up time was between 5 and 21 months. The best-corrected visual acuity before MSK was 0.20 LogMAR (median) and improved to 0.10 after the surgical procedure. The mean spherical equivalent was reduced from -0.23 ± 3.39 D preoperatively to -1.3 ± 3.0 D postoperatively. Astigmatism decreased between 0.5 and 3.75 D. Topographic irregularity normalized total root mean square from 11,596.4 ± 6854.01 to 4817.2 ± 2725.68 μm.
CONCLUSIONS: MSK is an effective and safe technique for the treatment of Salzmann nodular degeneration when the Bowman layer is preserved. Anterior segment optical coherence tomography and corneal topography are essential tools for the surgical plan and for the detection of corneal aberrations.
METHODS: This was a descriptive, retrospective study. All patients with a clinical diagnosis of Salzmann nodular degeneration were examined at the Cornea Service of the Instituto Clínico Quirúrgico de Oftalmología (ICQO), Bilbao, Spain, and treated with MSK after presenting ocular discomfort and/or decreased visual acuity. The clinical characteristics (including anterior segment optical coherence tomography and Pentacam topography), treatment regimens, surgical procedures, and outcomes were recorded. Descriptive statistics were constructed using mean ± SD, minimum, maximum, and median. The Shapiro-Wilk normality test was used. The Student t test was used to determine significance.
RESULTS: Ten eyes of 9 patients were included in this study: 6 patients (66.6%) were female and 3 were male (33.3%). The mean age was 62.2 years, and the follow-up time was between 5 and 21 months. The best-corrected visual acuity before MSK was 0.20 LogMAR (median) and improved to 0.10 after the surgical procedure. The mean spherical equivalent was reduced from -0.23 ± 3.39 D preoperatively to -1.3 ± 3.0 D postoperatively. Astigmatism decreased between 0.5 and 3.75 D. Topographic irregularity normalized total root mean square from 11,596.4 ± 6854.01 to 4817.2 ± 2725.68 μm.
CONCLUSIONS: MSK is an effective and safe technique for the treatment of Salzmann nodular degeneration when the Bowman layer is preserved. Anterior segment optical coherence tomography and corneal topography are essential tools for the surgical plan and for the detection of corneal aberrations.
摘要：
目的：本研究旨在描述Salzmann结节变性的人工浅表角膜切除术（MSK）后的光学和地形变化。
方法：这是一个描述性的，回顾性研究。所有临床诊断为萨尔茨曼结节变性的患者均在ClínicoQuirúrgicodeOftalloga研究所（ICQO）的角膜服务处进行了检查，毕尔巴鄂,西班牙,并在出现眼部不适和/或视力下降后接受MSK治疗。临床特征（包括眼前节光学相干断层扫描和Pentacam地形图），治疗方案,外科手术,并记录结果。使用平均值±SD构建描述性统计数据，minimum,最大值,和中位数。使用Shapiro-Wilk正态检验。使用Studentt检验来确定显著性。
结果：本研究纳入9例患者的10只眼：6例（66.6%）为女性，3例（33.3%）为男性。平均年龄为62.2岁,随访时间为5～21个月。MSK前的最佳矫正视力为0.20LogMAR（中位数），手术后提高到0.10。平均球形当量从术前-0.23±3.39D降低至术后-1.3±3.0D。散光在0.5至3.75D之间降低。地形不规则性归一化总均方根从11,596.4±6854.01降至4817.2±2725.68μm。
结论：当Bowman层保留时，MSK是治疗Salzmann结节变性的一种有效且安全的技术。前段光学相干断层扫描和角膜地形图是手术计划和检测角膜像差的重要工具。
方法：这是一个描述性的，回顾性研究。所有临床诊断为萨尔茨曼结节变性的患者均在ClínicoQuirúrgicodeOftalloga研究所（ICQO）的角膜服务处进行了检查，毕尔巴鄂,西班牙,并在出现眼部不适和/或视力下降后接受MSK治疗。临床特征（包括眼前节光学相干断层扫描和Pentacam地形图），治疗方案,外科手术,并记录结果。使用平均值±SD构建描述性统计数据，minimum,最大值,和中位数。使用Shapiro-Wilk正态检验。使用Studentt检验来确定显著性。
结果：本研究纳入9例患者的10只眼：6例（66.6%）为女性，3例（33.3%）为男性。平均年龄为62.2岁,随访时间为5～21个月。MSK前的最佳矫正视力为0.20LogMAR（中位数），手术后提高到0.10。平均球形当量从术前-0.23±3.39D降低至术后-1.3±3.0D。散光在0.5至3.75D之间降低。地形不规则性归一化总均方根从11,596.4±6854.01降至4817.2±2725.68μm。
结论：当Bowman层保留时，MSK是治疗Salzmann结节变性的一种有效且安全的技术。前段光学相干断层扫描和角膜地形图是手术计划和检测角膜像差的重要工具。
