PDF(Pubmed)
Abstract：
Central nervous system (CNS) tumors are the second most common type of cancer and the most common cause of cancer death in pediatric patients. New therapies are desperately needed for some of the most malignant of all cancers. Immunotherapy has emerged in the past two decades as an additional avenue to augment/replace traditional therapies (such as chemotherapy, surgery, and radiation therapy). This article first discusses the unique nature of the pediatric CNS immune system and how it interacts with the systemic immune system. It then goes on to review three important and widely studied types of immune therapies: checkpoint inhibitors, vaccines, and radiation therapy, and touches on early studies of antibody-mediated immunogenic therapies, Finally, the article discusses the importance of combination immunotherapy for pediatric CNS tumors, and addresses the neurologic toxicities associated with immunotherapies.
摘要：
中枢神经系统（CNS）肿瘤是第二种最常见的癌症类型，也是儿科患者癌症死亡的最常见原因。对于所有最恶性的癌症中的一些，迫切需要新的疗法。在过去的二十年中，免疫疗法已成为增强/取代传统疗法的另一种途径（例如化学疗法，手术,和放射治疗）。本文首先讨论了小儿中枢神经系统免疫系统的独特性质以及它如何与全身免疫系统相互作用。然后，它继续回顾三种重要且广泛研究的免疫疗法：检查点抑制剂，疫苗,和放射治疗,以及早期抗体介导的免疫原性疗法的研究，最后,本文讨论了联合免疫治疗对小儿中枢神经系统肿瘤的重要性，并解决了与免疫疗法相关的神经毒性。
