PDF(Pubmed)
Abstract：
Guillain-Barré syndrome (GBS) is an immune-mediated disorder that affects the peripheral nerves, often leading to weakness, numbness, and paralysis. Although GBS does not induce immunosuppression, severe cases can render patients vulnerable to infection due to various complications. We present the case of a 70-year-old woman who developed GBS following a Mycoplasma infection. The patient\'s prolonged GBS symptoms led to an immunocompromised state, resulting in sepsis due to bacteremia caused by methicillin-resistant Staphylococcus epidermidis. Respiratory muscle paralysis necessitated intubation and mechanical ventilation, predisposing the patient to aspiration pneumonia. Prolonged hospitalization increases the risk of infection, as exemplified by catheter-related bloodstream infections and respiratory bacterial colonization. Although GBS does not inherently suppress immunity, its complications, such as musculoskeletal and respiratory failure, can mimic immunodeficiency, necessitating comprehensive management. A system-based approach should address neurological deficits and potential complications, emphasizing collaboration among medical specialties. This case highlights the importance of recognizing GBS-related challenges and adopting a holistic strategy for effective patient care.
摘要：
格林-巴利综合征（GBS）是一种免疫介导的疾病，影响周围神经，经常导致软弱，麻木,和瘫痪。虽然GBS不诱导免疫抑制，严重的病例会使患者由于各种并发症而容易感染。我们介绍了一名70岁女性在支原体感染后发展为GBS的情况。患者的长期GBS症状导致免疫受损状态，导致由耐甲氧西林表皮葡萄球菌引起的菌血症引起的败血症。呼吸肌麻痹需要插管和机械通气，易患吸入性肺炎。住院时间延长会增加感染的风险,例如导管相关的血流感染和呼吸道细菌定植。虽然GBS本身并不抑制免疫力，其并发症,如肌肉骨骼和呼吸衰竭，可以模拟免疫缺陷，需要全面管理。基于系统的方法应该解决神经功能缺损和潜在的并发症，强调医学专业之间的合作。此案例强调了认识到GBS相关挑战并采用整体策略进行有效患者护理的重要性。
