UNASSIGNED: One hundred thirty-eight adolescents, assigned female sex at birth, with a continuum of NSSI severity completed negative and positive urgency measurements (self-report), an emotional Go/NoGo task within negative and positive contexts (behavioral), and structural and functional imaging during resting state and task (brain metrics). Cortical thickness, subcortical volume, resting-state functional connectivity, and task activation focused on an a priori-defined CC network. Eighty-four participants had all these main measures. Correlations and stepwise model selection followed by multiple regression were used to examine the association between NSSI severity and multiunit CC measurements.
UNASSIGNED: Higher NSSI severity correlated with higher negative urgency and lower accuracy during positive no-inhibition (Go). Brain NSSI severity correlates varied across modalities and valence. For right medial prefrontal cortex and right caudate, higher NSSI severity correlated with greater negative but lower positive inhibition (NoGo) activation. The opposite pattern was observed for the right dorsolateral prefrontal cortex. Higher NSSI severity correlated with lower left dorsal anterior cingulate cortex (ACC) negative inhibition activation and thicker left dorsal ACC, yet it was correlated with higher right rostral ACC positive inhibition activation and thinner right rostral ACC, as well as lower CC network resting-state functional connectivity.
UNASSIGNED: Findings revealed multifaceted signatures of NSSI severity across CC units of analysis, confirming the relevance of this domain in adolescent NSSI and illustrating how multimodal approaches can shed light on psychopathology.
■一百三十八个青少年,出生时指定的女性性别,在NSSI严重程度连续的情况下,完成了消极和积极的紧急测量(自我报告),消极和积极环境(行为)中的情绪化Go/NoGo任务,以及静息状态和任务(大脑指标)期间的结构和功能成像。皮质厚度,皮质下体积,静息状态功能连接,任务激活集中在先验定义的CC网络上。84名参与者采取了所有这些主要措施。相关性和逐步模型选择,然后进行多元回归,以检查NSSI严重程度与多单位CC测量之间的关联。
■在阳性无抑制(Go)期间,较高的NSSI严重程度与较高的负紧迫性和较低的准确性相关。脑NSSI严重程度在不同的模式和效价之间存在相关性。对于右内侧前额叶皮质和右尾状,较高的NSSI严重程度与较高的阴性但较低的阳性抑制(NoGo)激活相关。在右背外侧前额叶皮层观察到相反的模式。较高的NSSI严重程度与左下背前扣带皮质(ACC)负抑制激活和较厚的左背ACC相关,然而,它与较高的右延髓ACC阳性抑制激活和较薄的右延髓ACC相关,以及较低的CC网络静息状态功能连通性。
■研究结果揭示了跨CC分析单位的NSSI严重性的多方面特征,确认该领域在青少年NSSI中的相关性,并说明多模式方法如何阐明精神病理学。