PDF(Pubmed)
Abstract：
The correlation between L-type amino acid transporter 1 (LAT1) expression and 4-borono-2-18 F-fluoro-phenylalanine (18 F-FBPA) accumulation in humans remains unclear. This study aimed to investigate the correlation between LAT1 expression in tumor tissues and 18 F-FBPA accumulation in patients with head and neck cancer who participated in a clinical trial of 18 F-FBPA positron emission tomography (PET).
Altogether, 28 patients with head and neck cancer who participated in a clinical trial of 18 F-FBPA PET at our institution between March 2012 and January 2018 were included. Correlations between standardized uptake values (SUVs); the maximum SUV (SUVmax ), the mean SUV within a 1 cm3 sphere centered at a single point, that is, the SUVmax (SUVpeak ), the minimum SUV (SUVmin ), and the intensity of LAT1 expression (maximum and minimum LAT1 expressions) were investigated.
Weak correlations were identified between SUVmax and LAT1 maximum score, SUVmin and LAT1 maximum score, and SUVmin and LAT1 minimum score (ρ = 0.427, 0.362, and 0.330, respectively). SUVmax and LAT1 minimum score, SUVpeak and LAT1 maximum score, and SUVpeak and LAT1 minimum score demonstrated moderate correlations (ρ = 0.535, 0.556, and 0.661, respectively). Boron neutron capture therapy (BNCT) was performed in 2 of the 4 patients with discrepancies between 18 F-FBPA accumulation and intensity of LAT1 expression, and the intensity of LAT1 expression was a better predictor of treatment response.
18 F-FBPA accumulation and the intensity of LAT1 expression demonstrated a moderate correlation; however, LAT1 expression may be a better predictor of treatment response of BNCT in patients with discrepancies.
Altogether, 28 patients with head and neck cancer who participated in a clinical trial of 18 F-FBPA PET at our institution between March 2012 and January 2018 were included. Correlations between standardized uptake values (SUVs); the maximum SUV (SUVmax ), the mean SUV within a 1 cm3 sphere centered at a single point, that is, the SUVmax (SUVpeak ), the minimum SUV (SUVmin ), and the intensity of LAT1 expression (maximum and minimum LAT1 expressions) were investigated.
Weak correlations were identified between SUVmax and LAT1 maximum score, SUVmin and LAT1 maximum score, and SUVmin and LAT1 minimum score (ρ = 0.427, 0.362, and 0.330, respectively). SUVmax and LAT1 minimum score, SUVpeak and LAT1 maximum score, and SUVpeak and LAT1 minimum score demonstrated moderate correlations (ρ = 0.535, 0.556, and 0.661, respectively). Boron neutron capture therapy (BNCT) was performed in 2 of the 4 patients with discrepancies between 18 F-FBPA accumulation and intensity of LAT1 expression, and the intensity of LAT1 expression was a better predictor of treatment response.
18 F-FBPA accumulation and the intensity of LAT1 expression demonstrated a moderate correlation; however, LAT1 expression may be a better predictor of treatment response of BNCT in patients with discrepancies.
摘要：
背景：人类中L型氨基酸转运蛋白1（LAT1）表达与4-硼-2-18F-氟-苯丙氨酸（18F-FBPA）积累之间的相关性尚不清楚。这项研究旨在研究参与18F-FBPA正电子发射断层扫描（PET）临床试验的头颈部癌症患者中LAT1在肿瘤组织中的表达与18F-FBPA积累之间的相关性。
方法：总之，纳入了2012年3月至2018年1月在我们机构参加18F-FBPAPET临床试验的28例头颈部癌症患者。标准化摄取值(SUV)之间的相关性；最大SUV(SUVmax)，以一个点为中心的1cm3球体内的平均SUV，也就是说,SUVmax（SUVpeak），最小SUV（SUVmin），并研究了LAT1表达的强度（最大和最小LAT1表达）。
结果：在SUVmax和LAT1最大评分之间发现弱相关性，SUVmin和LAT1最大评分，和SUVmin和LAT1最低得分（ρ分别为0.427、0.362和0.330）。SUVmax和LAT1最低得分，SUVpeak和LAT1最大评分，SUVpeak和LAT1最低得分显示中等相关性(ρ分别为0.535、0.556和0.661)。4例患者中有2例进行了硼中子俘获治疗（BNCT），其中18F-FBPA积累与LAT1表达强度之间存在差异，LAT1表达的强度是治疗反应的更好预测指标。
结论：18F-FBPA积累与LAT1表达强度呈中等相关性；然而，LAT1表达可能是差异患者BNCT治疗反应的更好预测指标。
方法：总之，纳入了2012年3月至2018年1月在我们机构参加18F-FBPAPET临床试验的28例头颈部癌症患者。标准化摄取值(SUV)之间的相关性；最大SUV(SUVmax)，以一个点为中心的1cm3球体内的平均SUV，也就是说,SUVmax（SUVpeak），最小SUV（SUVmin），并研究了LAT1表达的强度（最大和最小LAT1表达）。
结果：在SUVmax和LAT1最大评分之间发现弱相关性，SUVmin和LAT1最大评分，和SUVmin和LAT1最低得分（ρ分别为0.427、0.362和0.330）。SUVmax和LAT1最低得分，SUVpeak和LAT1最大评分，SUVpeak和LAT1最低得分显示中等相关性(ρ分别为0.535、0.556和0.661)。4例患者中有2例进行了硼中子俘获治疗（BNCT），其中18F-FBPA积累与LAT1表达强度之间存在差异，LAT1表达的强度是治疗反应的更好预测指标。
结论：18F-FBPA积累与LAT1表达强度呈中等相关性；然而，LAT1表达可能是差异患者BNCT治疗反应的更好预测指标。
