PDF(Pubmed)
Abstract：
Basal cell carcinoma (BCC) is the most common form of cancer, with a high impact on the public health burden and social costs. Despite the overall prognosis for patients with BCC being excellent, if lesions are allowed to progress, or in a small subset of cases harboring an intrinsically aggressive biological behavior, it can result in local spread and significant morbidity, and conventional treatments (surgery and radiotherapy) may be challenging. When a BCC is not amenable to either surgery or radiotherapy with a reasonable curative intent, or when metastatic spread occurs, systemic treatments with Hedgehog inhibitors are available. These guidelines were developed, applying the GRADE approach, on behalf of the Italian Association of Medical Oncologists (AIOM) to assist clinicians in treating patients with BCC. They contain recommendations with regard to the diagnosis, treatment and follow-up, from primitive tumors to those locally advanced or metastatic, addressing the aspects of BCC management considered as priorities by a panel of experts selected by AIOM and other national scientific societies. The use of these guidelines in everyday clinical practice should improve patient care.
摘要：
基底细胞癌（BCC）是最常见的癌症，对公共卫生负担和社会成本有很大影响。尽管BCC患者的总体预后良好，如果允许病变进展，或者在一小部分具有内在攻击性生物学行为的病例中，它会导致局部传播和显著的发病率，和常规治疗（手术和放疗）可能是具有挑战性的。当BCC不适合具有合理治疗意图的手术或放疗时，或者当转移扩散发生时，可以使用Hedgehog抑制剂进行全身治疗。制定了这些指导方针，应用等级方法，代表意大利医学肿瘤学家协会（AIOM）协助临床医生治疗BCC患者。它们包含有关诊断的建议，治疗和随访，从原始肿瘤到局部晚期或转移性肿瘤，解决由AIOM和其他国家科学协会选出的专家小组认为是优先事项的BCC管理方面。在日常临床实践中使用这些指南应改善患者护理。
