Abstract：
The present study aimed to assess the impact of grape seed extract (GSE), onion peel extract (OPE), and rosemary extract (ROE) on Diquat-induced growth restriction and oxidative stress in Lohmann chicks. A total of 200 chicks were randomly assigned to 5 diets: the positive control (PC) group, the negative control (NC) group, GSE group, OPE group, and ROE group. During the first 7 d of trial, compared with NC and PC groups, the GSE group enhanced average daily feed intake (ADFI). From day 8-21, diquat injection resulted in reduced growth performance, increased platelet volume distribution width (PWD), malondialdehyde (MDA) concentration, and activities of alanine aminotransferase (ALT) in chick serum; it also decreased total protein (TP), albumin (ALB), globulin (GLB) concentration, activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) in chick serum; furthermore, it increased MDA concentration while decreasing GST activities in liver. The NC group exhibited lower average daily gain (ADG) than other groups. Compared with NC group, GSE group reduced ALT activities, MDA levels, and red cell distribution width (RDW), and PDW concentration; it also increased SOD, GST activities. The ROE group lowered ALT activities and MDA concentration. The OPE group decreased ALT activities, and MDA levels, RDW, and PDW concentration, and increased SOD activities of chicks. These results suggest that supplementing antioxidants in diets alleviated oxidative stress in chicks challenged by improving antioxidant capacity and liver function.
摘要：
本研究旨在评估葡萄籽提取物（GSE）的影响，洋葱皮提取物（OPE），迷迭香提取物（ROE）对Diquat引起的Lohmann雏鸡生长限制和氧化应激的影响。共有200只小鸡被随机分配到5种饮食中：阳性对照（PC）组，阴性对照（NC）组，GSE组,OPE集团,ROE集团。在审判的前7天，与NC和PC组相比，GSE组提高了平均日采食量(ADFI)。从第8-21天开始，注射敌快导致生长性能下降，增加血小板体积分布宽度（PWD），丙二醛（MDA）浓度，和丙氨酸氨基转移酶（ALT）的活性在鸡血清；它也降低总蛋白（TP），白蛋白（ALB），球蛋白（GLB）浓度，鸡血清中超氧化物歧化酶(SOD)和谷胱甘肽硫转移酶(GST)的活性;它增加MDA浓度，同时降低肝脏GST活性。NC组的平均日增重（ADG）低于其他组。与NC组相比,GSE组ALT活性降低,MDA水平,和红细胞分布宽度(RDW)，和PDW浓度；它也增加了SOD，GST活动。ROE组降低ALT活性和MDA浓度。OPE组ALT活性下降，和MDA水平，RDW,和PDW浓度，增加雏鸡的SOD活性。这些结果表明，在饮食中补充抗氧化剂可以通过改善抗氧化能力和肝功能来减轻雏鸡的氧化应激。
