Abstract：
BACKGROUND: Metastasis to the gallbladder is very rare. This case report highlights a rare cause of acute cholecystitis, which should be considered by the surgeon and other treating physicians in the differential diagnosis of patients with urothelial carcinoma.
METHODS: We report the case of a 73 year-old man with follow-up oncology care. He was diagnosed with infiltrating urothelial carcinoma in 2019, received neoadjuvant chemotherapy, and subsequently underwent radical cystectomy with ureteroileostomy in April 2020. Histology confirmed complete regression of bladder cancer, the lymphonodes were also free of tumour infiltration. In July 2021, the patient was examined for intermittent abdominal pain, predominantly of the right upper quadrant. On clinical examination, the gallbladder hydrops was palpable and a positive Murphy\'s sign was present. Due to the signs of acute cholecystitis, the patient was indicated for acute cholecystectomy. Gallbladder histology revealed metastatic involvement of the gallbladder wall by urothelial carcinoma.
CONCLUSIONS: If patients with bladder cancer present with intermittent right subcostal pain or signs of acute cholecystitis and diagnostic imaging shows a thickened gallbladder wall, clinicians and radiologists should consider the possibility of metastatic origin of lesion.
METHODS: We report the case of a 73 year-old man with follow-up oncology care. He was diagnosed with infiltrating urothelial carcinoma in 2019, received neoadjuvant chemotherapy, and subsequently underwent radical cystectomy with ureteroileostomy in April 2020. Histology confirmed complete regression of bladder cancer, the lymphonodes were also free of tumour infiltration. In July 2021, the patient was examined for intermittent abdominal pain, predominantly of the right upper quadrant. On clinical examination, the gallbladder hydrops was palpable and a positive Murphy\'s sign was present. Due to the signs of acute cholecystitis, the patient was indicated for acute cholecystectomy. Gallbladder histology revealed metastatic involvement of the gallbladder wall by urothelial carcinoma.
CONCLUSIONS: If patients with bladder cancer present with intermittent right subcostal pain or signs of acute cholecystitis and diagnostic imaging shows a thickened gallbladder wall, clinicians and radiologists should consider the possibility of metastatic origin of lesion.
摘要：
背景：胆囊转移非常罕见。此病例报告强调了急性胆囊炎的罕见原因，在尿路上皮癌患者的鉴别诊断中，外科医生和其他治疗医师应考虑这一点。
方法：我们报告了一例73岁男性患者的肿瘤学随访。2019年诊断为浸润性尿路上皮癌，接受新辅助化疗，随后于2020年4月接受了根治性膀胱切除术和输尿管回肠造口术.组织学证实膀胱癌完全消退，淋巴结也没有肿瘤浸润。2021年7月，患者接受了间歇性腹痛检查，主要位于右上象限。在临床检查中，胆囊积液明显，墨菲的体征呈阳性。由于急性胆囊炎的迹象，患者接受急性胆囊切除术.胆囊组织学显示尿路上皮癌转移累及胆囊壁。
结论：如果膀胱癌患者出现间歇性右肋下疼痛或急性胆囊炎征象，影像学诊断显示胆囊壁增厚，临床医生和放射科医师应考虑病灶转移来源的可能性.
方法：我们报告了一例73岁男性患者的肿瘤学随访。2019年诊断为浸润性尿路上皮癌，接受新辅助化疗，随后于2020年4月接受了根治性膀胱切除术和输尿管回肠造口术.组织学证实膀胱癌完全消退，淋巴结也没有肿瘤浸润。2021年7月，患者接受了间歇性腹痛检查，主要位于右上象限。在临床检查中，胆囊积液明显，墨菲的体征呈阳性。由于急性胆囊炎的迹象，患者接受急性胆囊切除术.胆囊组织学显示尿路上皮癌转移累及胆囊壁。
结论：如果膀胱癌患者出现间歇性右肋下疼痛或急性胆囊炎征象，影像学诊断显示胆囊壁增厚，临床医生和放射科医师应考虑病灶转移来源的可能性.
