PDF(Pubmed)
Abstract：
UNASSIGNED: Immune dysfunction plays a pivotal role in sepsis pathogenesis. Previous studies have revealed the crucial role of T cells and human leukocyte antigen-DR (HLA-DR) in sepsis. However, the function of natural killer (NK) cells remains unclear. This study aimed to investigate whether NK cells are associated with sepsis prognosis. In addition, we aimed to explore the interrelation and influence between NK and other immunological features in patients with sepsis.
UNASSIGNED: This retrospective, observational study included patients with sepsis from two hospitals in mainland China. The clinical characteristics and immune results during the early phase were collected. Patients were classified according to the level of immune cells to analyze the relationship between immunological features and 28-day mortality.
UNASSIGNED: A total of 984 patients were included in this study. Non-survivors were older and had lower levels of lymphocytes, monocytes, NK cells, HLA-DR, and T cells. Patients were classified into eight groups according to their levels of NK cells, HLA-DR, and T cells. Only patients with decreased NK and T cell counts showed a significant increase in 28-day mortality. An increase in CD8+ T cells was correlated with the alleviation of 28-day mortality only among patients with high NK cell levels.
UNASSIGNED: This study provides novel insights into the association between NK cells and 28-day mortality as well as the interrelation between NK cells and other immune cells in sepsis. The relationship between CD8+ T cells and 28-day mortality in sepsis is dependent on NK cell count.
UNASSIGNED: This retrospective, observational study included patients with sepsis from two hospitals in mainland China. The clinical characteristics and immune results during the early phase were collected. Patients were classified according to the level of immune cells to analyze the relationship between immunological features and 28-day mortality.
UNASSIGNED: A total of 984 patients were included in this study. Non-survivors were older and had lower levels of lymphocytes, monocytes, NK cells, HLA-DR, and T cells. Patients were classified into eight groups according to their levels of NK cells, HLA-DR, and T cells. Only patients with decreased NK and T cell counts showed a significant increase in 28-day mortality. An increase in CD8+ T cells was correlated with the alleviation of 28-day mortality only among patients with high NK cell levels.
UNASSIGNED: This study provides novel insights into the association between NK cells and 28-day mortality as well as the interrelation between NK cells and other immune cells in sepsis. The relationship between CD8+ T cells and 28-day mortality in sepsis is dependent on NK cell count.
摘要：
■免疫功能障碍在脓毒症发病机制中起着关键作用。先前的研究揭示了T细胞和人类白细胞抗原-DR（HLA-DR）在脓毒症中的关键作用。然而,自然杀伤（NK）细胞的功能尚不清楚。本研究旨在探讨NK细胞是否与脓毒症预后相关。此外,我们旨在探讨脓毒症患者NK与其他免疫学特征之间的相互关系和影响。
■这次回顾展，观察性研究纳入了中国大陆两家医院的脓毒症患者。收集早期的临床特征和免疫结果。根据免疫细胞水平对患者进行分类，以分析免疫学特征与28天死亡率之间的关系。
■本研究共纳入984例患者。非幸存者年龄较大，淋巴细胞水平较低，单核细胞,NK细胞,HLA-DR,和T细胞。根据患者的NK细胞水平分为八组，HLA-DR,和T细胞。只有NK和T细胞计数减少的患者显示28天死亡率显着增加。仅在具有高NK细胞水平的患者中,CD8+T细胞的增加与28天死亡率的减轻相关。
■这项研究为NK细胞与28天死亡率之间的关联以及NK细胞与脓毒症中其他免疫细胞之间的相互关系提供了新的见解。脓毒症中CD8+T细胞与28天死亡率之间的关系取决于NK细胞计数。
■这次回顾展，观察性研究纳入了中国大陆两家医院的脓毒症患者。收集早期的临床特征和免疫结果。根据免疫细胞水平对患者进行分类，以分析免疫学特征与28天死亡率之间的关系。
■本研究共纳入984例患者。非幸存者年龄较大，淋巴细胞水平较低，单核细胞,NK细胞,HLA-DR,和T细胞。根据患者的NK细胞水平分为八组，HLA-DR,和T细胞。只有NK和T细胞计数减少的患者显示28天死亡率显着增加。仅在具有高NK细胞水平的患者中,CD8+T细胞的增加与28天死亡率的减轻相关。
■这项研究为NK细胞与28天死亡率之间的关联以及NK细胞与脓毒症中其他免疫细胞之间的相互关系提供了新的见解。脓毒症中CD8+T细胞与28天死亡率之间的关系取决于NK细胞计数。
