PDF(Pubmed)
Abstract：
Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis is characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. Ferroptosis is involved in a variety of physiological and pathological processes. Since its discovery, ferroptosis has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress and prospects, summarize the regulatory mechanisms of ferroptosis, and discuss the role of ferroptosis in the pathogenesis of bone-related diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), and osteosarcoma (OS), as well as its therapeutic potential.
摘要：
Ferroptosis是近年来发现的一种新的细胞命运决定。与细胞凋亡不同,自噬或焦亡，铁死亡的特征是铁依赖性脂质过氧化和线粒体形态变化。铁凋亡参与多种生理和病理过程。自从它被发现,关于骨相关疾病的研究越来越多。在这次审查中,我们关注最新的研究进展和前景，概述铁死亡的调控机制，探讨铁性凋亡在骨相关疾病发病机制中的作用,如骨质疏松症（OP），骨关节炎（OA），类风湿性关节炎(RA),和骨肉瘤（OS），以及它的治疗潜力。
