Abstract：
Postorgasmic illness syndrome (POIS) is a rare syndrome in which patients experience various physical and cognitive symptoms after ejaculation, and its pathophysiology remains unknown.
The aim of this study was to characterize the clinical presentations, disease course, and treatment outcomes in outpatients, as well as to examine the validity of the preliminary criteria and symptom clusters of POIS.
This retrospective monocentric study was conducted in a neurourology department, with patients included from 2010 to 2023. The diagnostic criteria and symptom cluster descriptions were based on previous studies.
The study focused on the clinical features of POIS, the complementary tests performed, the treatments tried, and their effectiveness.
Thirty-seven men were included in the study, with symptom onset occurring at a mean ± SD age of 23.6 ± 7.4 years. The mean time from ejaculation to symptom onset was 1 hour 22 minutes ± 3 hours 42 minutes. The mean duration of symptoms was 4.7 ± 3.4 days. Seventeen patients (46%) developed the symptoms primarily, whereas in 20 (54%) they appeared secondarily. All preliminary criteria were met in 19 patients (51%). The most common symptom clusters were \"general\" in all 37 patients (100%; eg, asthenia and concentration difficulties) and \"head\" in 35 patients (95%; mostly headache and a foggy feeling). In terms of treatments, antihistamines and nonsteroidal anti-inflammatory drugs were tried and partially improved symptoms for some patients.
This study helps to further characterize POIS by specifying the most frequent symptoms and comparing them with the initial criteria.
To our knowledge, this is one of the largest cohorts of patients consulting for symptoms suggestive of POIS. There are limitations due to the retrospective nature of the data collection, such as missing data and imprecision of treatment efficacy.
The majority of participants met at least 3 of the preliminary diagnostic criteria, with a majority of symptoms in the general and head clusters. However, the determination of predictive factors for treatment response based on the typology of the disorders remains to be established.
The aim of this study was to characterize the clinical presentations, disease course, and treatment outcomes in outpatients, as well as to examine the validity of the preliminary criteria and symptom clusters of POIS.
This retrospective monocentric study was conducted in a neurourology department, with patients included from 2010 to 2023. The diagnostic criteria and symptom cluster descriptions were based on previous studies.
The study focused on the clinical features of POIS, the complementary tests performed, the treatments tried, and their effectiveness.
Thirty-seven men were included in the study, with symptom onset occurring at a mean ± SD age of 23.6 ± 7.4 years. The mean time from ejaculation to symptom onset was 1 hour 22 minutes ± 3 hours 42 minutes. The mean duration of symptoms was 4.7 ± 3.4 days. Seventeen patients (46%) developed the symptoms primarily, whereas in 20 (54%) they appeared secondarily. All preliminary criteria were met in 19 patients (51%). The most common symptom clusters were \"general\" in all 37 patients (100%; eg, asthenia and concentration difficulties) and \"head\" in 35 patients (95%; mostly headache and a foggy feeling). In terms of treatments, antihistamines and nonsteroidal anti-inflammatory drugs were tried and partially improved symptoms for some patients.
This study helps to further characterize POIS by specifying the most frequent symptoms and comparing them with the initial criteria.
To our knowledge, this is one of the largest cohorts of patients consulting for symptoms suggestive of POIS. There are limitations due to the retrospective nature of the data collection, such as missing data and imprecision of treatment efficacy.
The majority of participants met at least 3 of the preliminary diagnostic criteria, with a majority of symptoms in the general and head clusters. However, the determination of predictive factors for treatment response based on the typology of the disorders remains to be established.
摘要：
背景：中风后疾病综合征（POIS）是一种罕见的综合征，患者在射精后会出现各种身体和认知症状，其病理生理学仍然未知。
目的：本研究的目的是表征临床表现，病程,和门诊患者的治疗结果，以及检查POIS的初步标准和症状群的有效性。
方法：这项回顾性单中心研究是在神经内科进行的，患者包括2010年至2023年。诊断标准和症状群描述基于先前的研究。
结果：该研究集中于POIS的临床特征，进行的补充测试，尝试的治疗方法，和他们的有效性。
结果：37名男性被纳入研究，症状发生在平均±SD年龄23.6±7.4岁。从射精到症状发作的平均时间为1小时22分钟±3小时42分钟。症状的平均持续时间为4.7±3.4天。17名患者（46％）主要出现症状，而在20（54％）中，它们是次要出现的。19例患者（51%）符合所有初步标准。在所有37例患者中，最常见的症状群是“一般”(100%；例如，虚弱和注意力不集中）和35例患者的“头”（95％；主要是头痛和雾状）。在治疗方面,我们尝试了抗组胺药和非甾体类抗炎药,部分改善了部分患者的症状.
结论：这项研究有助于通过指定最常见的症状并将其与初始标准进行比较来进一步表征POIS。
■据我们所知，这是咨询提示POIS症状的最大患者队列之一.由于数据收集的回顾性性质，存在局限性，如数据缺失和治疗效果不精确。
结论：大多数参与者至少符合3项初步诊断标准，大多数症状在一般和头部集群。然而,根据疾病的类型确定治疗反应的预测因素仍有待确定。
目的：本研究的目的是表征临床表现，病程,和门诊患者的治疗结果，以及检查POIS的初步标准和症状群的有效性。
方法：这项回顾性单中心研究是在神经内科进行的，患者包括2010年至2023年。诊断标准和症状群描述基于先前的研究。
结果：该研究集中于POIS的临床特征，进行的补充测试，尝试的治疗方法，和他们的有效性。
结果：37名男性被纳入研究，症状发生在平均±SD年龄23.6±7.4岁。从射精到症状发作的平均时间为1小时22分钟±3小时42分钟。症状的平均持续时间为4.7±3.4天。17名患者（46％）主要出现症状，而在20（54％）中，它们是次要出现的。19例患者（51%）符合所有初步标准。在所有37例患者中，最常见的症状群是“一般”(100%；例如，虚弱和注意力不集中）和35例患者的“头”（95％；主要是头痛和雾状）。在治疗方面,我们尝试了抗组胺药和非甾体类抗炎药,部分改善了部分患者的症状.
结论：这项研究有助于通过指定最常见的症状并将其与初始标准进行比较来进一步表征POIS。
■据我们所知，这是咨询提示POIS症状的最大患者队列之一.由于数据收集的回顾性性质，存在局限性，如数据缺失和治疗效果不精确。
结论：大多数参与者至少符合3项初步诊断标准，大多数症状在一般和头部集群。然而,根据疾病的类型确定治疗反应的预测因素仍有待确定。
